Proteolysis of Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3) by human placental trophoblasts: A potential source for the pregnancy-associated serum IGFBP-3 protease

Irwin, Jane A.; Suen, Lii-Fang; Giudice, L.C.

doi:10.1016/s1071-5576(97)86118-7

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“…Studies with cytotrophoblast monolayer cultures and with decidualized endometrial stromal cells in culture demonstrate that the cytotrophoblast se cretes an IGFBP-3 protease. 34 The placenta thus ap pears to be the site of origin of the pregnancy serum IGFBP-3, which first appears in the maternal circulation at about 6 weeks of gestation and is barely detectable by 5 days postpartum. 35 ' 36 This protease decreases the affinity of IGFBP-3 for radio labeled IGF-II >IGF-I and increases IGF bioavail ability believed to be important in maternal tissue growth and perhaps placental growth.…”

Section: The Igf Family In At the Decidual: Trophoblast Interfacementioning

confidence: 99%

Roles of the Insulinlike Growth Factor Family in Nonpregnant Human Endometrium and at the Decidual:Trophoblast Interface

Giudice

Irwin²

1999

Semin Reprod Med

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The insulinlike growth factor (IGF) family is believed to be important in endometrial development during the menstrual cycle and in the process of implantation. The mitogenic, differentiative, and antiapoptotic properties of the IGFs and their binding proteins, as well as their spatial and temporal expression in cycling endometrium, suggest that they may participate in endometrial growth, differentiation, apoptosis, and perhaps angiogenesis. IGFBP proteases, which increase IGF bioavailability, have been localized to endometrial stromal cells and to the human cytotrophoblast and likely play important roles in endometrial, decidual, and trophoblast physiology. IGFBP-1 is a major protein product of nonpregnant endometrium during the mid-late secretory phase and occurs in abundance in decidua. Its roles as an IGF-binding protein and as a trophoblast integrin ligand suggest that it may have multiple roles in endometrial development and in interactions between the decidua and the invading trophoblast. Recent evidence suggests that it may have a role in the process of shallow implantation in the clinical disorder of preclampsia. In contrast to knowledge about the roles of IGF peptides, IGFBP proteases, and IGFBPs in normal endometrial development and early human pregnancy, little information is available regarding this family in abnormal endometrial development, in occult endometrial defects, and in uterine receptivity and nonreceptivity.

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Section: The Igf Family In At the Decidual: Trophoblast Interfacementioning

confidence: 99%