Proteoglycans remodeling in cancer: Underlying molecular mechanisms

Decorin‐mediated oncosuppression – a potential future adjuvant therapy for human epithelial cancers

“…Identical results have been reported in pancreatic cancer (Skandalis et al, ). Although decorin core protein is the primary structure in the sequestering of various growth factors, a GAG rich in chondroitin sulfate with specific sulfation patterns can interact with, for example, fibroblast growth factor 2 (Theocharis and Karamanos, ). Subsequently, this leads to the activation of the MAPK pathway and to malignant transformation (Theocharis and Karamanos, ).…”

“…Recently, several studies focusing on decorin in tumourigenesis have, together, indicated that decorin is a potent oncosuppressive molecule (Neill et al, ; Theocharis and Karamanos, ; Schaefer et al, ). Originally, this was observed when mice lacking both decorin and p53 were shown to exhibit a faster rate of tumour growth than p53 null animals, suggesting that the lack of decorin was tumour‐permissive (Iozzo et al, ).…”

“…Originally, this was observed when mice lacking both decorin and p53 were shown to exhibit a faster rate of tumour growth than p53 null animals, suggesting that the lack of decorin was tumour‐permissive (Iozzo et al, ). Today, we know that in different malignancies such as breast cancer, bladder cancer and colon cancer, the expression of decorin is markedly decreased (Theocharis and Karamanos, ), so that the malignant cells of these carcinomas do not express decorin (Boström et al, ; Sainio et al, ; Nyman et al, ). On the other hand, the delivery of decorin or the induction of its expression in carcinoma cells has been shown to attenuate the malignant behaviour of cells through a variety of mechanisms (Bi and Yang, ; Neill et al, ; Boström et al, ).…”

Developing DNA methylation‐based prognostic biomarkers of acute myeloid leukemia

“…2 genes were upregulated genes and 3 genes were downregulated genes. 40 In addition, as shown in Table 1, the GO analysis revealed that these enriched genes are mainly involved in cell adhesion, the negative regulation of transcription from the RNA polymerase II promoter and cAMP-mediated signaling, protein kinase binding, sequence-specific DNA binding, and regulatory region DNA binding. AML, acute myeloid leukemia pathway, the overexpression of which can promote tumor cell growth.…”

Proteoglycans in normal physiology and carcinogenesis

“…Злокачественная трансформация клеток практи-чески всегда ассоциирована со значительными изме-нениями структуры, состава, локализации и функцио-нальных характеристик ПГ, являющихся неотъемлемой частью как самих клеток, так и их микроокружения [39,40].…”