Proteoglycans from the cartilage of young hammerhead shark Sphyrna lewini

Michelacci, Yára M.; Horton, Denise S. P. Q.

doi:10.1016/0305-0491(89)90245-9

Cited by 23 publications

(22 citation statements)

References 30 publications

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“…Elasmobranch cartilage contains one third type I collagen and the remaining portion is type II (Rama and Chandrakasan, 1984). Proteoglycans are the major noncollagenous organic component in elasmobranch cartilage (Michelacci and Horton, 1989). They add compressive strength to mammalian cartilage by increasing the swelling pressure through their hydrophilic interactions with water (Koob, 1989;Koob and Vogel, 1987).…”

Section: Introductionmentioning

confidence: 99%

Material properties and biochemical composition of mineralized vertebral cartilage in seven elasmobranch species (Chondrichthyes)

Porter

Beltran

Koob³

et al. 2006

Journal of Experimental Biology

100

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SUMMARY Elasmobranchs, particularly sharks, function at speed and size extremes,exerting large forces on their cartilaginous skeletons while swimming. This casts doubt on the generalization that cartilaginous skeletons are mechanically inferior to bony skeletons, a proposition that has never been experimentally verified. We tested mineralized vertebral centra from seven species of elasmobranch fishes: six sharks and one axially undulating electric ray. Species were chosen to represent a variety of morphologies, inferred swimming speeds and ecological niches. We found vertebral cartilage to be as stiff and strong as mammalian trabecular bone. Inferred swimming speed was a good, but not infallible, predictor of stiffness and strength. Collagen content was also a good predictor of material stiffness and strength, although proteoglycan was not. The mineral fraction in vertebral cartilage was similar to that in mammalian trabecular bone and was a significant predictor of material properties.

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Section: Introductionmentioning

confidence: 99%

Material properties and biochemical composition of mineralized vertebral cartilage in seven elasmobranch species (Chondrichthyes)

Porter

Beltran

Koob³

et al. 2006

Journal of Experimental Biology

100

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“…Proteoglycans (PGs) are the major non-collagenous organic elements of elasmobranch cartilage (Michelacci and Horton 1989). These PGs contain side-chain glycosaminoglycans (GAGs), primarily 90% chondroitin 6-sulfate and 10% keratan sulfate (Michelacci and Horton 1989).…”

Section: Introductionmentioning

confidence: 99%

“…These PGs contain side-chain glycosaminoglycans (GAGs), primarily 90% chondroitin 6-sulfate and 10% keratan sulfate (Michelacci and Horton 1989). The proteoglycan monomers of elasmobranch cartilage appear to have higher hydrodynamic sizes than those of mammalian cartilage, essentially due to the larger size of GAG chains in the former (Michelacci and Horton 1989). The majority of PGs in mammalian cartilage are typically aggregated, due to their interaction with hyaluronic acid (Hascall and Heinegard 1974).…”

Section: Introductionmentioning

confidence: 99%

Proteoglycans from the vertebral cartilage of the clearnose skate, Raja eglanteria: Inhibition of hydroxyapatite formation

Gelsleichter

Musick

Veld

1995

Fish Physiol Biochem

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Studies were undertaken to examine the importance of organic proteoglycan matrices in the calcification of elasmobranch vertebral cartilage. Proteoglycans were extracted from the vertebral cartilage of the clearnose skate, Raja eglanteria Bosc, with a 3M guanidine hydrochloride/10% EDTA solution. Proteoglycan solutions (12 μg ml(-1)) were effective inhibitors of hydroxyapatite formation in vitro from high concentration calcium phosphate solutions. Inhibition of crystal formation appears to occur through the restriction of phase transformation from a calcium phosphate precursor to hydroxyapatite crystals. The concentration and/or degradation of proteoglycans in elasmobranch vertebral cartilage may have a physiological role in the production of alternating mineral-rich and mineral-poor growth zones, currently used in ageing studies.

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“…O condroitim 4-sulfato ocorre com maior abundância nas cartilagens que se acham em estágio de crescimento e de ossificação 15,39,41,42 . O condroitim 4-sulfato é também registrado em alguns estados patológicos como artrose, calo ósseo, condromas e condrossarcomas 39,42 .…”

Section: Introductionunclassified

“…Por outro lado, a localização preferencial do condroitim 6-sulfato na matriz das cartilagens articulares 39,40,42 e na matriz extracelular da aorta de várias espécies animais 43,44 sugere que ele esteja envolvido com a manutenção da integridade dos tecidos sujeitos a altas pressões. Atua como inibidor de proteases extracelulares envolvidas no metabolismo do tecido conjuntivo, inibindo a produção de citocinas 45,46 .…”

Section: Introductionunclassified

Perfil dos glicosaminoglicanos no útero de ratas ooforectomizadas e tratadas com estrogênios e/ou progestagênios

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Proteoglycans from the cartilage of young hammerhead shark Sphyrna lewini

Cited by 23 publications

References 30 publications

Material properties and biochemical composition of mineralized vertebral cartilage in seven elasmobranch species (Chondrichthyes)

Material properties and biochemical composition of mineralized vertebral cartilage in seven elasmobranch species (Chondrichthyes)

Proteoglycans from the vertebral cartilage of the clearnose skate, Raja eglanteria: Inhibition of hydroxyapatite formation

Perfil dos glicosaminoglicanos no útero de ratas ooforectomizadas e tratadas com estrogênios e/ou progestagênios

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