“…Cartilage proteo-1959;Anderson et al, 1964;Mathews & Glasgov, glycans are complex polydisperse macromolecules 1966; Hjertquist & Engfeldt, 1967, and references consisting of chondroitin sulphate, keratan sulphate cited therein; Greiling & Stuhlsatz, 1969; Bjelle et (Rosenberg et al, 1975(Rosenberg et al, , 1976Hardingham et al, al., 1972;Hjertquist & Lemperg, 1972;Hjertquist & 1976;Heinegard & Axelsson, 1977; Heinegird, Wasteson, 1972;Lemperg et al, 1974;Mankin & 1977; Hascall & Heinegard, 1979) and oligo-saccharide side chains covalently linked to a protein core . Several studies (Hoffman et al, 1975;Hopwood & Robinson, 1975;Roughley & Mason, 1976;Stanescu et al, 1977;Swann et al, 1979) have also shown that articular cartilage contains different types of proteoglycans and significant quantities of protein and glycoprotein constituents. There is therefore the possibility that the gross chemical changes may reflect alterations in the structure and/or the proportions of the different types of macromolecular components.…”