Proteobacteria-specific IgA regulates maturation of the intestinal microbiota

Dietary energy level affects the composition of cecal microbiota of starter Pekin ducklings

“…Moreover, diversity index, including Chao1 richness, Simpson diversity, and Shannon diversity index were all lower than those of the previous study (Vasai et al 2014). Proteobacteria is also a dominant phylum present in newborn mice, but it is suppressed in normal adult microbiota (Mirpuri et al 2014). Similarly, the differences between the present study and the previous report of Vasai et al (2014) might be attributed to the increased age of ducks, a situation which has been recorded in chickens and humans (Gong et al 2008;Nicholson et al 2012).…”

IL-33 regulates the IgA-microbiota axis to restrain IL-1α–dependent colitis and tumorigenesis

“…Intestinal IgA is one such immune component that preferentially targets colitogenic members of the microbiota, including SFB and A. muciniphila (34,39,41,56,57). Reciprocally, certain pathobionts can produce proteolytic enzymes that degrade intestinal IgA and thereby enhance colitis susceptibility (40).…”

Proteobacteria: microbial signature of dysbiosis in gut microbiota

“…Above all, the abundance of Proteobacteria in the neonatal gut is affected by the type of feeding, with a higher frequency of these bacteria in formula-fed infants, but a scarcity in breast-fed infants (reviewed in [75]). Human milk oligosaccharides [76] and secretory IgA production [77] are involved in the selective suppression of Proteobacteria during the initial intestinal colonization process. Therefore, a reduction in the abundance of Proteobacteria in a timely manner after its blooming is increasingly thought to be a normal part of the initial microbial colonization, and disturbance of this colonization pattern is linked to an increased risk of neonatal diseases [78,79].…”