Proteinuria in Pre‐eclampsia

Simanowitz, M. D.; MacGregor, W. G.; Hobbs, J. R.

doi:10.1111/j.1471-0528.1973.tb02162.x

Cited by 20 publications

(2 citation statements)

References 17 publications

(7 reference statements)

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“…Proteinuria is usually preceded by a reduced uric acid clearance, so that a rising maternal plasma urate concentration is an earlier renal indicator of pre-eclampsia (Redman et al' 1976) which correlates well with the renal biopsy changes of the disorder (Pollak & Nettles 1960). The proteinuria is characteristically of intermediate selectivity (McEwan 1968(McEwan , 1969Maclean et al 1972;Simanowitz et al 1973).…”

mentioning

confidence: 99%

Urinary albumin excretion in pregnancy

Lopez-Espinoza¹,

Dhar²,

Humphreys³

et al. 1986

BJOG

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Summary. Urinary albumin excretion during pregnancy has been studied using a sensitive radioimmunoassay. One hundred pregnant women attending a high‐risk antenatal clinic and 14 normal pregnant women were investigated serially, during pregnancy and post‐partum. The normal subjects showed a small but significant rise in albumin excretion in the third trimester, which was sustained pre‐delivery and in the first postnatal week. Twenty‐six women were classified as having mild pre‐eclampsia and 44 as having chronic hypertension without evidence of superimposed pre‐eclampsia. In neither group was there evidence of proteinuria by conventional testing, nor was the median albumin excretion different from normal antenatally; in the first week after delivery a significant increase was observed, but this regressed to normal 6 weeks later. Eight patients developed severe pre‐eclampsia, of whom one had evidence of underlying renal disease. Three presented with proteinuria already established. In the remaining five patients, the shift from normal to high albumin excretion occurred rapidly, usually preceded by a rise in uric acid and a decrease in the platelet count. These data suggest that proteinuric pre‐eclampsia, as defined by relatively insensitive routine laboratory measurement, is not preceded by a phase of increasing albumin loss which can be detected by more sensitive assays.

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confidence: 99%

Urinary albumin excretion in pregnancy

Lopez-Espinoza¹,

Dhar²,

Humphreys³

et al. 1986

BJOG

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“…As the glomerular abnormality in pre-eclampsia is minimal (Pollack and Nettles, 1960) it is difficult to explain the reduced uric acid clearance on the basis of impaired glomerular filtration. There is, however, a considerable amount of evidence to support the hypothesis that renal cortical ischaemia, secondary to the reduced renal blood flow demonstrated in pre-eclampsia, is a more important factor (Seitchik, 1953;Altchek, 1964;Simanowitz, MacGregor and Hobbs, 1973). These authors conclude that the primary cause of hyperuricaemia is an increased reabsorption or decreased secretion of uric acid by the kidney tubules rather than decreased glomerular filtration.…”

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confidence: 99%

Changes Ln Serum Uric Acid Concentrations After Caesarean Section Using Methoxyflurane

Hamilton¹,

Robertson²,

Campbell³

1975

British Journal of Anaesthesia

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Morphologic changes in the renal glomerulus and the juxtaglomerular apparatus in human preeclampsia

Hill

Fairley

Kincaid‐Smith

et al. 1988

The Journal of Pathology

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The renal biopsies of ten women with preeclampsia without other underlying renal disease were examined in detail using light and electron microscopy and immunofluorescence. Characteristic preeclamptic glomerular lesions with endocapillary cell swelling, subendothelial and mesangial deposits, and mesangial interposition were detected in each patient. Juxtaglomerular regions were not prominent and were poorly granulated on light microscopy; ultrastructurally, they showed myoepithelioid cells with sparse renin granulation and considerable heterogeneity of granule size and density in association with relatively meagre granular endoplasmic reticulum and Golgi profiles. These morphologic findings suggest that, in patients with clinical and renal biopsy evidence of preeclampsia, there is no significant stimulation of the renin-angiotensin system.

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Proteinuria in Pre‐eclampsia

Cited by 20 publications

References 17 publications

Urinary albumin excretion in pregnancy

Urinary albumin excretion in pregnancy

Changes Ln Serum Uric Acid Concentrations After Caesarean Section Using Methoxyflurane

Morphologic changes in the renal glomerulus and the juxtaglomerular apparatus in human preeclampsia

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