Proteinuria as the Most Relevant Parameter Affecting Fetuin-A Levels in Preeclampsia

Al‐Hakeim, Hussein Kadhem; Ali, Roaa Ali Muhammed

doi:10.1515/afmnai-2015-0027

Cited by 3 publications

(3 citation statements)

References 41 publications

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“…The major finding of Table 1 is the increase in the circulating angiogenesis biomarkers in women with PE compared with those in control women. BMI and WHR are significantly high in women with PE [19,20]. The increase in BMI may be due to the oedema in the patient group that is associated with proteinuria [20].…”

Section: Characteristics Clinical and Circulating Angiogenesis Biomamentioning

confidence: 97%

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Effect of Serum Copper on Circulating Angiogenesis-Related Factors in Women with Preeclampsia

Nadheer¹,

Zahraei²,

Al‐Hakeim³

2019

Preprint

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Preeclampsia (PE) is characterized by a series of clinical features such as hypertension and proteinuria associated with endothelial dysfunction and the impairment of placenta vascular endothelial integrity. This study aimed to investigate the effect of serum copper (Cu) level on some angiogenesis-related factors including vascular endothelial growth factor-A (VEGF-A), soluble Fms-like tyrosine kinase-1 (sVEGF-R1), soluble endoglin (sEng) and cerruloplasmin (Cp) in Iraqi women with preeclampsia (PE) and control pregnant women. Therefore, 60 women with PE in addition to 30 healthy pregnant women were enrolled in the study. Serum concentration of sEng, VEGF-A, sVEGF-R1, and Cu in PE group significantly increased (p<0.05) in the PE group compared with that in the control group. Increased production of antiangiogenic factors, soluble VEGF-A and sEng contribute to the pathophysiology of PE, indicating the involvement of these parameters in the angiogenic balance in patients with PE. Tests for between-subject effects showed that the circulating angiogenesis factors and Cu were significantly associated with the presence of PE. Serum Cu level was significantly correlated with VEGF- A and VEGF-R1 levels but not with sEng. Multiple regression analysis revealed that only Cp and BP can significantly predict the complications in women with PE. In conclusion, serum Cu has a role in the angiogenesis in women with PE and may be a new drug target in the prevention or treatment of PE.

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Section: Characteristics Clinical and Circulating Angiogenesis Biomamentioning

confidence: 97%

“…BMI and WHR are significantly high in women with PE [19,20]. The increase in BMI may be due to the oedema in the patient group that is associated with proteinuria [20]. Increases in BMI in the normal range are also associated with an increased risk of PE [21].…”

Section: Characteristics Clinical and Circulating Angiogenesis Biomamentioning

confidence: 99%

Effect of Serum Copper on Circulating Angiogenesis-Related Factors in Women with Preeclampsia

Nadheer¹,

Zahraei²,

Al‐Hakeim³

2019

Preprint

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“…As depicted in Figure 1, the apelin levels of patients with PE are lower than those of the controls [8,28] given that pregnant women excrete high amounts of protein in their urine [29]. Apelin levels reflect the cardiovascular changes associated with pregnancy.…”

Section: -Apelin Levelsmentioning

confidence: 99%

Serum Apelin and Galactin-3 in Preeclampsia in Iraq

Taha¹,

Zahraei²,

Al‐Hakeim³

2019

Preprint

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Preeclampsia (PE) is a common pregnancy complication. It is associated with high maternal morbidity and mortality rates and intrauterine foetal growth restriction. This condition is characterised by high blood pressure and urinary protein levels. Apelin and galectin-3 (Gal- 3) are peptides involved in the regulation of body fluid homeostasis, inflammation and cardiovascular functions. This study aimed to determine the correlations amongst serum apelin and Gal-3 levels and insulin resistance (IR) in women with PE. Sixty patients with PE and 30 healthy controls participated in this study. The PE group had significantly lower apelin levels (p < 0.01) and higher Gal-3 levels (p < 0.05) than the control group. The PE group had higher serum glucose levels and β-cell functions than the control group. Moreover, patients with PE exhibited dyslipidaemia. Correlation analysis indicated that apelin and Gal-3 levels were not significantly correlated. Moreover, no correlation existed between the apelin levels and any measured parameters of the PE group. In conclusion, the elevations in serum Gal-3 levels with increments in IR-related parameters and lipid profiles reflect the possible contribution of Gal-3 to the harmful effects of IR and dyslipidemia levels on women with PE.

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