Proteinuria, a marker of cardiovascular risks

Maheshwari, Anuj

doi:10.15406/jdmdc.2018.05.00167

Cited by 2 publications

(2 citation statements)

References 39 publications

(40 reference statements)

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“…This study also showed a statistically significant association between proteinuria and DM concordant comorbidities. In line with studies conducted in Bangladesh ( 14 ), India ( 41 ), and Korea ( 42 ) DM patients with positive proteinuria had higher odds of having concordant comorbidity. This could be because proteinuria impairs the kidneys’ capacity to remove waste products.…”

Section: Discussionsupporting

confidence: 84%

Factors associated with diabetes concordant comorbidities among adult diabetic patients in Central Ethiopia: a cross-sectional study

Negussie,

Getahun,

Bekele

2023

Front. Clin. Diabetes Healthc.

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BackgroundDiabetes comorbidities are a serious public health issue that raises the risk of adverse health effects and complicates diabetes management. It also harms emotional health, medication adherence, self-management, and general quality of life. However, evidence is scarce in Ethiopia, particularly in the study area. Thus, this study aimed to estimate the prevalence of diabetes concordant comorbidities and identify factors associated with the presence of concordant comorbidities among adult diabetic patients in central Ethiopia.MethodsA health facility-based cross-sectional study was conducted among 398 adult diabetic patients. A computer-generated simple random sampling was used to select study participants. Data were collected using a structured data extraction checklist. The collected data were entered into Epi info version 7.2 and exported to SPSS version 27 for analysis. A binary logistic regression model was used to analyze the association between dependent and independent variables. An adjusted odds ratio with the corresponding 95% confidence interval was used to measure the strength of the association and statistical significance was declared at a p-value < 0.05.ResultThe prevalence of diabetes-concordant comorbidities was 41% (95% CI: 36.2-46.0). The multivariable logistic regression model showed that age 41–60 (AOR = 2.86, 95% CI: 1.60–5.13), place of residence (AOR = 2.22, 95% CI: 1.33–3.70), having type two diabetes (AOR = 3.30, 95% CI: 1.21–8.99), and having positive proteinuria (AOR = 2.64, 95% CI: 1.47–4.76) were significantly associated with diabetes concordant comorbidities.ConclusionThe prevalence of diabetes-concordant comorbidities was relatively high. Age, place of residence, type of diabetes, and positive proteinuria were factors associated with diabetes-concordant comorbidities. Prevention, early identification, and proper management of diabetes comorbidities are crucial.

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Section: Discussionsupporting

confidence: 84%

Factors associated with diabetes concordant comorbidities among adult diabetic patients in Central Ethiopia: a cross-sectional study

Negussie,

Getahun,

Bekele

2023

Front. Clin. Diabetes Healthc.

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“…Von Willebrand factors, soluble vascular cell adhesion molecule, fibrinogen, and tissue plasminogen activator along with elevated CRP level have been implicated to be potential thrombogenic factors for cardiovascular events. 10 Immunosuppressive agents are also known to cause increased cardiovascular risk factors such as high blood pressure, high lipids, and high blood sugar. However, in recent study mycophenolate is found to be beneficial which confers protective effects against ischemia/ reperfusion injury, through its immunosuppressive and antiinflammatory actions.…”

Section: Case Reportmentioning

confidence: 99%

Acute St-Segment Elevation Myocardial Infarction in a Young Patient With Iga Nephropathy: A Rare Case Report

Hussain¹,

Regmi²,

Dhital³

et al. 2022

JCMC

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Cardiovascular events are less commonly described in glomerular disease. However, thromboembolic events are quite commonly reported in glomerular disease with nephrotic range proteinuria. Here, we report a case of a 29 years old male with IgA nephropathy present with central chest pain radiating to the jaw. He was under mycophenolate, prednisolone and losartan with remission of proteinuria for two months. ECG showed extensive ST segment elevation in V1- V6 leads. His cardiac troponins were elevated. Coronary angiography showed complete thrombotic occlusion of mid left anterior descending artery which was successfully recanalized after primary percutaneous intervention. Though less commonly reported in literature, such incidence of coronary events in IgA nephropathy can rarely present with acute myocardial infarction.

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Proteinuria, a marker of cardiovascular risks

Cited by 2 publications

References 39 publications

Factors associated with diabetes concordant comorbidities among adult diabetic patients in Central Ethiopia: a cross-sectional study

Factors associated with diabetes concordant comorbidities among adult diabetic patients in Central Ethiopia: a cross-sectional study

Acute St-Segment Elevation Myocardial Infarction in a Young Patient With Iga Nephropathy: A Rare Case Report

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