Proteinstatus bei kurzfristigem Fasten und bei Zufuhr essentieller Aminosäuren

Gofferje, H; Kozlik, V.

doi:10.1159/000220061

Cited by 2 publications

(2 citation statements)

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“…Immune dysfunction has been observed in chronically undernourished subjects [47]. Starvation itself for 5-10 days does not affect immunoglobulin levels [48][49][50] and an increase has been observed in obese subjects during fasting [51]. However, it remains to be shown whether reduced immunoglobulins (Table 4) is due to a synergistic effect of exercise and starvation.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Strenuous Exercise, Calorie Deficiency and Sleep Deprivation on White Blood Cells, Plasma Immunoglobulins and Cytokines

Bøyum

Wiik

Gustavsson³

et al. 1996

Scand J Immunol

133

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Moderate exercise appears to stimulate the immune system, but there is good evidence that intense exercise can cause immune deficiency. In the present study the authors examined the effect of continuous physical exercise (35% of VO2 max), calorie deficiency and sleep deprivation on the immune system of young men participating in a 5–7 days military training course. There was a two–three fold increase of neutrophils from day 1, the values remained high and decreased slightly at the end of the course. Monocyte counts also increased with a pattern similar to that of neutrophils. Eosinophils decreased to 30% of control and lymphocyte numbers decreased by 30–40%. All the major subgroups (CD4 T cells , CD8 T cells, B cells, NK cells) were reduced. Neutrophil function, as tested by measuring chemotaxis, was significantly stimulated during the first days of the course, in particular in the group with the lowest calorie intake. The mitogenic response of lymphocytes to PHA and Con A was variable, ranging from stimulation during one course to no effect in another course. Serum levels of immunoglobulins decreased significantly during the course. IgG was reduced by 6–7%, IgA by 10–20% and IgM by 20–35%. The authors found no changes of interleukin 1, 2 and 4 during the course, but a (12–20%) reduction (P<0.01) of interleukin 6 , and an increase (P<0.01) of granulocyte–macrophage colony stimulating factor. Altogether the results from the ranger course present a mixed‐up picture. The non‐specific phagocyte‐related immunity was enhanced. On the other hand, the data indicate that even a moderate physical activity, around the clock, caused significant suppression of a number of parameters reflecting the status of the specific, lymphocyte‐related immunity. It is noteworthy, however, that there was no significantly increased infection rate during the course or in the first 4–5 weeks thereafter.

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Section: Discussionmentioning

confidence: 99%

The Effect of Strenuous Exercise, Calorie Deficiency and Sleep Deprivation on White Blood Cells, Plasma Immunoglobulins and Cytokines

Bøyum

Wiik

Gustavsson³

et al. 1996

Scand J Immunol

133

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“…So existieren auch einige Arbeiten zum Einfluss des Fastens auf verschiedene immunologische Parameter. Neben der Aktivierung zellulärer Immunkomponenten (Monozyten, natürliche Killerzellen) wurde dabei fast durchgehend auch ein Anstieg der Antikör-pertiter einschliesslich Serum-IgA beobachtet [17,18,32,45]. Die Auswirkungen des Fastens auf den Gehalt an sIgA im Stuhl, also die lokale Schleimhautimmunität im Darm, wurden dagegen noch nicht untersucht.…”

Section: Introductionunclassified

Verläufe des sekretorischen Immunglobulins A des Darms und Befindlichkeit von Patienten unter naturheilkundlicher Therapie und Heilfasten

Rüffer²,

Balles³

et al. 2001

Complement Med Res

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Change of the Secretory Immunoglobulin A and the Condition of the Patients during Naturopathic Therapy and Heal-Fasting Therapy Background: In clinical observations it was noticed that patients who have been treated with naturopathic methods – especially with the treatment of heal fasting – experience a stabilization of their immune system. The immune system stands in close relation to the intestinal flora and influences the condition of the patient. Question: For this reason the influence of a 3-week in-hospital naturopathic therapy – among others a heal-fasting therapy –, a corresponding follow-up on the intestine-associated immune system as well as the condition of the patients have been examined. Patients and Methods: Classical naturopathic treatments based on standardized therapy concepts were applied. The patients (n = 55) showed different kinds of basic diseases, whereof in 56% of the cases the patients suffered of diseases of the skeleton, the muscles, and the connective tissue. The patients got a 3-week standardized high-quality nutrition or they took part in a juice-modified fasting therapy. The state of the local endogenous defense system within the intestine was measured by the concentration of the secretory immunoglobulin A (sIgA) in the feces of the patients. A positive criterion was a sIgA concentration in the stool of under 0.5 mg/g. Additionally the judgement of the patients concerning their own condition (‘quality of life’) was determined by the condition scale. Results: It was shown that the content of the sIgA within the stool was increased during the course of the in-hospital stay, in the complete population of patients as well as in the different subgroups ‘with heal-fasting’ and ‘without heal-fasting’. Even in the follow-up analysis it could be observed that 3 months after the treatment the content of secretory IgA in the stool of all groups was between 0.78 and 0.89 mg/g. This value was significantly higher than the starting values. The most intensive effects concerning the change of sIgA were measured within the group of the patients who performed heal fasting (Ε > 1.0). Aside from the increase of the secretory IgA, a mediocre improvement of the condition of the patients within the pre-post comparison could be noticed, but no correlation between the secretory IgA values and the values concerning the condition was found. Conclusion: A 3-week in-hospital therapy with classical naturopathic treatments (but especially the application of the heal-fasting therapy) leads to a significant improvement of the immune condition of the intestine and consequently of the whole organism. The improving effect lasts beyond the stay in hospital.

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Proteinstatus bei kurzfristigem Fasten und bei Zufuhr essentieller Aminosäuren

Cited by 2 publications

References 0 publications

The Effect of Strenuous Exercise, Calorie Deficiency and Sleep Deprivation on White Blood Cells, Plasma Immunoglobulins and Cytokines

The Effect of Strenuous Exercise, Calorie Deficiency and Sleep Deprivation on White Blood Cells, Plasma Immunoglobulins and Cytokines

Verläufe des sekretorischen Immunglobulins A des Darms und Befindlichkeit von Patienten unter naturheilkundlicher Therapie und Heilfasten

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