Proteins of Wnt signaling pathway in cancer stem cells of human glioblastoma

Шевченко, В. Е.; Arnotskaya, N. E.; Zaitsev, Sergei; Sharma, Aruna; Sharma, Hari Shanker; Bryukhovetskiy, Andrey; Pak, Oleg; Bryukhovetskiy, Igor

doi:10.1016/bs.irn.2020.03.006

Cited by 15 publications

(9 citation statements)

References 50 publications

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“…According with this overall increase in WNT activation in GBM, protein expression of the DVL family is also enhanced in this tumor (167)(168)(169). Interestingly, autophagic decrease in DVL2 levels impairs b-catenin nuclear localization, concomitant with an epithelial-like phenotype (114).…”

Section: Crosstalk Between Autophagy Epithelial-mesenchymal Transitimentioning

confidence: 86%

Multifaceted WNT Signaling at the Crossroads Between Epithelial-Mesenchymal Transition and Autophagy in Glioblastoma

et al. 2020

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Section: Crosstalk Between Autophagy Epithelial-mesenchymal Transitimentioning

confidence: 86%

Multifaceted WNT Signaling at the Crossroads Between Epithelial-Mesenchymal Transition and Autophagy in Glioblastoma

et al. 2020

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“…Besides, the tyrosine phosphorylation of DAAM1 modulates its homodimer formation and actin polymerization, which is essential for lung cancer invasiveness [ 17 ]. Besides, DAAM1 is found to be upregulated in CD133 + cancer stem cells, suggesting its critical role in the maintenance of tumor cell stemness [ 28 ]. In this research, we validated that DAAM1 was upregulated in BrCa tissues and associated with poor prognosis, which was in accordance with previous observation with a small size of samples [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

YWHAZ interacts with DAAM1 to promote cell migration in breast cancer

Mei

Liu

et al. 2021

Cell Death Discov.

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Dishevelled-associated activator of morphogenesis 1 (DAAM1) is a critical driver in facilitating metastasis in breast cancer (BrCa). However, molecular mechanisms for the regulation of DAAM1 activation are only partially elucidated. In this research, the expression levels of YWHAZ and DAAM1 were examined by immunohistochemistry (IHC) staining in BrCa tissues. The functional roles of tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta (YWHAZ)–DAAM1 axis and their regulator microRNA-613 (miR-613) in BrCa cells and associated molecular mechanisms were demonstrated in vitro. As results, the expression levels of DAAM1 and YWHAZ were significantly upregulated in BrCa tissues compared with normal tissues and remarkably associated with poor prognosis. Besides, DAAM1 and YWHAZ were positively correlated with each other in BrCa tissues. YWHAZ interacted and colocalized with DAAM1 in BrCa cells, which was essential for DAAM1-mediated microfilament remodeling and RhoA activation. Moreover, miR-613 directly targeted both YWHAZ and DAAM1, contributing to inhibiting BrCa cells migration via blocking the complex of YWHAZ–DAAM1. To sum up, these data reveal that YWHAZ regulates DAAM1 activation, and the YWHAZ–DAAM1 complex is directly targeted by the shared post-transcriptional regulator miR-613.

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“…ROCK2 and CTSB gains or amplifications were shared among six samples (both STUMPs and LMSs). ROCK2 (Rho associated coiled-coil containing protein kinase 2) upregulation has been described in human glioblastoma CSCs [13], in gastric cancer [14], as well as in ovarian cancer samples [15]. Moreover, ROCK2 expression level has been associated with worse prognosis in osteosarcoma tissues [16].…”

Section: Discussionmentioning

confidence: 99%

Genomic and Epigenomic Profile of Uterine Smooth Muscle Tumors of Uncertain Malignant Potential (STUMPs) Revealed Similarities and Differences with Leiomyomas and Leiomyosarcomas

Conconi

Redaelli

Lissoni

et al. 2021

IJMS

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Uterine smooth muscle tumors of uncertain malignant potential (STUMPs) represent a heterogeneous group of tumors that cannot be histologically diagnosed as unequivocally benign or malignant. For this reason, many authors are working to obtain a better definition of diagnostic and prognostic criteria. In this work, we analyzed the genomic and epigenomic profile of uterine smooth muscle tumors (USMTs) in order to find similarities and differences between STUMPs, leiomyosarcomas (LMSs) and leiomyomas (LMs), and possibly identify prognostic factors in this group of tumors. Array-CGH data on 23 USMTs demonstrated the presence of a more similar genomic profile between STUMPs and LMSs. Some genes, such as PRKDC and PUM2, with a potential prognostic value, were never previously associated with STUMP. The methylation data appears to be very promising, especially with regards to the divergent profile found in the sample that relapsed, characterized by an overall CGI hypomethylation. Finally, the Gene Ontology analysis highlighted some cancer genes that could play a pivotal role in the unexpected aggressive behavior that can be found in some of these tumors. These genes could prove to be prognostic markers in the future.

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Proteins of Wnt signaling pathway in cancer stem cells of human glioblastoma

Cited by 15 publications

References 50 publications

Multifaceted WNT Signaling at the Crossroads Between Epithelial-Mesenchymal Transition and Autophagy in Glioblastoma

Multifaceted WNT Signaling at the Crossroads Between Epithelial-Mesenchymal Transition and Autophagy in Glioblastoma

YWHAZ interacts with DAAM1 to promote cell migration in breast cancer

Genomic and Epigenomic Profile of Uterine Smooth Muscle Tumors of Uncertain Malignant Potential (STUMPs) Revealed Similarities and Differences with Leiomyomas and Leiomyosarcomas

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