Proteins of the Central Nervous System in Pathology

Sande, M. Van

doi:10.1007/978-1-4615-7172-8_12

Handbook of Neurochemistry 1972

DOI: 10.1007/978-1-4615-7172-8_12

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Proteins of the Central Nervous System in Pathology

M. Van Sande¹

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1974

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Proteins of Human Brain Tissue Obtained During Surgical Procedures

Cain

Ball

Dekaban

1974

Journal of Neurochemistry

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Abstract— A series of normal and abnormal brain tissues were obtained during surgical procedures; adjacent portions were evaluated histologically or extracted with dilute buffer. The proteins were separated in acrylamide gels using electrophoresis and isoelectric focusing. Twelve of the patients showed a very similar distribution of the proteins on electrophoretic separation referred to as the ‘typical’ pattern. This group includes all of the histologically normal specimens, and in addition, one mild gliosis, two cases of juvenile lipidosis, one mucopolysaccharidosis and one Unverricht epilepsy. Remarkably little variability in the electrophoresis gel pattern was found in a series of five pairs of histologically normal gray and white matter samples. An increased density of several bands was apparent in extracts of gray matter when compared with corresponding white. No differences which could be correlated with the different areas of the cortex were seen. Six of the patients showed gel patterns different from the ‘typical’ pattern. One of these (glioblastoma) differed only in the increase in band 9. Another glioblastoma showed a virtual absence of nearly all of the brain proteins usually found in the gels. Two astrocytomas and one surgical scar specimen showed a very dense protein band (No. 15) and a novel minor protein component, band 20, while one case of SSPE showed only the heavy band in the area of band 15. The content of band 5 was reduced in those specimens which presented a dense band 15. The pronounced increase in band 15 and band 20 appears to correlate with the marked increase in astrocytic elements in these three patients.

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Proteins of Human Brain Tissue Obtained During Surgical Procedures

Cain

Ball

Dekaban

1974

Journal of Neurochemistry

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Proteins of the Central Nervous System in Pathology

Cited by 1 publication

References 86 publications

Proteins of Human Brain Tissue Obtained During Surgical Procedures

Proteins of Human Brain Tissue Obtained During Surgical Procedures

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