Proteins of Bovine Ephemeral Fever Virus

Walker, Peter; Byrne, Keren; Cybinski, D. H.; Doolan, Denise L.; Wang, Yonghong

doi:10.1099/0022-1317-72-1-67

Cited by 80 publications

(56 citation statements)

References 24 publications

(29 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The Beijing-1 strain of BEFV was isolated from the blood of an infected cow at Beijing, China in 1976 (Bai et al, 1987). The viruses were grown in BHK-21 cells at 37 mC in RPMI 1640 or BME medium supplemented with 14 mM HEPES, 10 % foetal calf serum, 100 U\ml penicillin and 100 µg\ml streptomycin as described previously (Walker et al, 1991(Walker et al, , 1992.…”

Section: Methodsmentioning

confidence: 99%

“…BEFV is serologically related to several other rhabdoviruses which infect cattle including Adelaide River virus (ARV), Berrimah virus and Kimberley virus (Calisher et al, 1989) and these have also been classified in the genus Ephemerovirus (Wunner et al, 1995). Like other rhabdoviruses, BEFV virions are bullet-or cone-shaped (Murphy et al, 1972), comprising a ribonucleoprotein complex and an envelope and containing a negative single-stranded RNA genome and five structural proteins (Della-Porta & Brown, 1979 ;Walker et al, 1991). Amino acid sequence analysis of the BEFV nucleoprotein (N) has indicated a close relationship to that of ARV and similarity to other animal rhabdoviruses with higher overall homology to vesiculoviruses than to lyssaviruses Wang et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

“…The first encodes the virion envelope glycoprotein (G) which contains type-specific and neutralizing antigenic sites (Cybinski et al, 1990) and protects cattle against experimental infection (Uren et al, 1994 ;Hertig et al, 1996). The second gene also encodes a class 1 transmembrane glycoprotein (G NS ) which has not been detected in virions and does not induce a protective or neutralizing immune response (Walker et al, 1991(Walker et al, , 1992Hertig et al, 1996). The G and G NS proteins are related to each other both in structure and in amino acid sequence and to virion G proteins of other rhabdoviruses and appear to have arisen by gene duplication (Wang & Walker, 1993).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Genome organization and transcription strategy in the complex GNS-L intergenic region of bovine ephemeral fever rhabdovirus.

McWilliam

Kongsuwan²,

Cowley³

et al. 1997

Journal of General Virology

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Genome organization and transcription strategy in the complex GNS-L intergenic region of bovine ephemeral fever rhabdovirus.

McWilliam

Kongsuwan²,

Cowley³

et al. 1997

Journal of General Virology

View full text Add to dashboard Cite

show abstract

“…For cross-neutralization experiments (Table 3), two 3-6 months old New Zealand white rabbits were immunized with Vaccine-1983, TN-1996, TN-1999 or TN-2001 isolate, and 2 unvaccinated rabbits served as negative controls. The virus was purified by ultracentrifugation [16] and mixed with an equal volume of complete Freund's adjuvant. The rabbits were immunized subcutaneously (SC).…”

Section: Serum Neutralization Antibody Test and Cross-neutralization mentioning

confidence: 99%

“…The causative ephemerovirus is bullet-shaped and consists of a minus sense, single-stranded RNA genome; five structural proteins, including one surface glycoprotein (G); and no nonstructural proteins. The surface glycoprotein induces the production of a protective neutralizing antibody [5,15,16]. The disease is characterized clinically by the sudden onset of fever, stiffness, lameness, nasal and ocular discharges, depression, cessation of rumination, and constipation.…”

mentioning

confidence: 99%

Bovine Ephemeral Fever in Taiwan (2001-2002)

Hsieh

Chen

Chou

et al. 2005

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

ABSTRACT. Bovine ephemeral fever (BEF), a vector-borne disease of cattle, is caused by the Ephemerovirus of the family Rhabdoviridae. In the past 40 years, Taiwan has had seven BEF epizootics, and we have previously reported the first five. This study summarizes the 2001 and 2002 epizootics; conducted case-control serologic studies on 10 herds involved in the 2001 epizootic; determined whether the recent BEF viruses have varied significantly; and discusses the relationship between epizootic patterns and possible variant BEF viruses. For mature cows that had received at least 2 doses of vaccine before the study, a negative correlation between the prevaccinated (the 3rd dose and after) serum neutralization antibody (SNA) titers and their postvaccinated peak rates was found. When prevaccinated SNA levels were at ≤ 32, their postvaccinated SNA levels increased significantly faster (P<0.01) than for those at ≥ 32. The glycoprotein gene of isolates from 1999, 2001, and 2002 had a 99.2-99.9% homology, without consistent amino acid variations in the neutralization sites. Phylogenetic analysis of Taiwanese isolates revealed 2 distinct clusters, the 1983-1989 and 1996-2002 isolates. Cross-neutralization tests confirmed the glycoprotein gene sequence analysis results. In conclusion, annual boosters at SNA levels > 32, at more than 2 doses, or at intervals shorter than 6 months are not advisable. The occurrence of frequent small epizootics implies the dominance of BEF virus over host immunity, but not a variant virus. KEY WORDS: bovine ephemeral fever, outbreak, serology, vaccination.

show abstract

Nucleosides and Nucleotides

Suhadolnik¹,

Reichenbach²

2000

Kirk-Othmer Encyclopedia of Chemical Technology

View full text Add to dashboard Cite

The naturally occurring nucleoside and nucleotide antibiotics exist as either the C ‐ or N ‐glycosides. They include ezomycin A 1 (C 26 H 38 N 8 O 15 S), ezomycin B 1 (C 26 H 39 N 7 O 17 S), ezomycin C 1 (C 26 H 37 N 7 O 16 S), ezomycin A 2 (C 19 H 26 N 6 O 12 ), ezomycin B 2 (C 19 H 25 N 5 O 13 ), ezomycin C 2 (C 19 H 25 N 5 O 13 ), showdomycin (C 9 H 11 NO 6 ), isoshowdomycin (C 9 H 11 NO 6 ), maleimycin (C 7 H 7 NO 3 ), oxazinomycin (C 9 H 11 NO 7 ), pyrazomycin (pyrazofurin) (C 9 H 13 N 3 O 6 ), formycin (C 10 H 13 N 5 O 4 ), formycin B (C 10 H 12 N 4 O 5 ), oxoformycin B (C 10 H 12 N 4 O 6 ). These antibiotics contain a variety of purine and pyrimidine rings. The naturally occurring nucleoside/nucleotide antibiotics, which have been isolated from bacteria, fungi, blue‐green algae, and marine sponges, have proven to be useful biochemical probes in eucaryotic, procaryotic, viral, fungal, and plant systems. The purine nucleosides inhibit protein synthesis, RNA and DNA synthesis, and methyltransferases; they have antimycoplasmal, antiviral, hypotensive, antifungal, antimycobacterial, and antitumor activities and induce sporulation. The pyrimidine nucleosides inhibit protein synthesis, virus replication, RNA and DNA synthesis, and cAMP phosphodiesterase. The imidazole nucleosides inhibit nucleic acid synthesis. The diazepin nucleosides inhibit adenosine deaminase (ADA). The indole nucleosides inhibit bacteria, yeast, fungi, and viruses. The N ‐nucleotide antibiotics include agrocin 84 (C 21 H 34 N 6 O 16 P 2 ), thuringiensin (C 22 H 30 N 5 O 19 P), phosmidosine (C 16 H 24 N 7 O 8 P), fosfadecin (C 13 H 19 N 5 O 10 P 2 ), and fosfocytocin (C 12 H 20 N 4 O 13 P 2 ). Thuringiensin, produced by B. thuringiensis , is a β‐exotoxin that exerts its toxic action on insects and mammals through the inhibition of RNA polymerases. Phosmidosine inhibits pore formation of Botrytis cinerea and Aspergillus niger . Fosfadecin and fosfocytocin inhibit gram‐positive and gram‐negative bacteria.

show abstract

Proteins of Bovine Ephemeral Fever Virus

Cited by 80 publications

References 24 publications

Genome organization and transcription strategy in the complex GNS-L intergenic region of bovine ephemeral fever rhabdovirus.

Genome organization and transcription strategy in the complex GNS-L intergenic region of bovine ephemeral fever rhabdovirus.

Bovine Ephemeral Fever in Taiwan (2001-2002)

Nucleosides and Nucleotides

Contact Info

Product

Resources

About