Proteins associated withCryptococcusspp. extracellular polysaccharides are implicated in virulence, capsule integrity, and biofilm formation
Piotr R. Stempinski,
Ella Jacobs,
Livia Liporagi Lopes
et al.
Abstract:Cryptococcus neoformans and Cryptococcus gattii are pathogenic fungi comprising species complexes that are the etiological agents of cryptococcosis. Both fungal species complexes possess a variety of virulence factors that include a polysaccharide capsule, melanin production, enzymes, and the release of polysaccharides. In this study, we characterized the proteins associated with cryptococcal polysaccharides and analyzed their function by studying mutants deficient in their expression. Mass spectrometry analys… Show more
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