Proteins and peptides from vegetable food sources as therapeutic adjuvants for the type 2 diabetes mellitus

Legume Proteins and Peptides as Compounds in Nutraceuticals: A Structural Basis for Dietary Health Effects

“…Small peptides, partially digested proteins and intact proteins from soybean, lupin, lentil, chickpea, pea, and the common bean, exert hormone-like activities [ 30 , 31 ]. Specific beneficial effects in humans include cardiovascular protection, anticancer activity, bone protection, control of weight, immune cell action, insulin sensitivity, control of inflammation and of type 2 diabetes mellitus [ 32 , 33 , 34 , 35 ]. Some examples of bioactive proteins and peptides derived from legume seeds are presented in Table 1 .…”

Protein-based nutritional strategies to manage the development of diabetes: evidence and challenges in human studies

“…16 In this sense, PYY has been proposed as a therapeutic gut hormone, although is quickly degraded by the DPP-IV. 9 Consequently, the inhibition of DPP-IV, which would have a positive effect on PYY and GLP-1, as previously described, by increasing their half-life, is seen as one of the most promising therapeutic strategies to manage T2DM.…”

“…8 Because of this DPP-IV activity, the circulating GLP-1 half-life is 1 to 2 minutes. 9 In the case where there is a lack of ability of the organism to react to the insulin action, or an insufficient production of this hormone, the subject is considered to have insulin resistance. This situation can evolve towards a metabolic disorder called diabetes, and this uncontrol of postprandial glucose level implies high glucose levels in the bloodstream, likely resulting in renal failure, neurological damage and/or cardiovascular disorders.…”

“…This situation can evolve towards a metabolic disorder called diabetes, and this uncontrol of postprandial glucose level implies high glucose levels in the bloodstream, likely resulting in renal failure, neurological damage and/or cardiovascular disorders. 9,10 Type 2 Diabetes Mellitus (T2DM) is one of the most prevalent diseases, affecting more than 537 million people and with estimations of 783 million people becoming affected by 2045. 11 This disease can be caused by both genetic and environmental factors, including obesity, because of an imbalance in the concentration of hormones, cytokines and other inflammatory signals.…”

Recent patent applications in beverages enriched with plant proteins

“…It is also known that di and tripeptides can be absorbed by the gut, and, as well as animal proteins, plant proteins can be hydrolyzed in biopeptides which present health-promoting effects. Some of these benefits are 17 , 18 , for example, anticancer, antimicrobial, antioxidant, anti-inflammatory, antianemic, antithrombotic, antihypertension, antiobesity, antidiabetic, and immunomodulatory activities 19 , 20 . These biopeptides normally do not present bioactivity when encrypted in the parent protein, so the benefit only displays after the hydrolysis process 21 .…”