Proteins

Wallace, Koranda

doi:10.1002/9781118718704.ch7

Cited by 1 publication

(7 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fibrinogen is classified as a moderate acute phase protein in the horse, and thus only increases up to 10-fold after an inflammatory stimulus. 1 Hyperfibrinogenemia is a common finding in horses with bacterial pneumonia and is present in 68% to 100% of horses, but only 35% of horses in this study. 6,8,9 Median plasma concentration of fibrinogen in this group of horses did not change significantly from day 0 until discharge (P = .06), nor was it correlated with SAA concentration over time.…”

Section: Discussionmentioning

confidence: 58%

“…Serum amyloid A (SAA) is a major acute phase protein in the horse, meaning that it is present in low to negligible concentrations in health but increases rapidly by >10‐fold after an acute inflammatory stimulus and decreases quickly after cessation of the stimulus 1 . It is higher in horses with infectious compared with horses with noninfectious upper respiratory disease and there is a significant difference in SAA concentration between horses with Streptococcus equi subsp.…”

Section: Introductionmentioning

confidence: 99%

“…but increases rapidly by >10-fold after an acute inflammatory stimulus and decreases quickly after cessation of the stimulus. 1 It is higher in horses with infectious compared with horses with noninfectious upper respiratory disease and there is a significant difference in SAA concentration between horses with Streptococcus equi subsp. equi infections and viral upper respiratory infections (EIV and EHV-4).…”

mentioning

confidence: 96%

“…7 An increase in plasma concentration of fibrinogen, a moderate acute phase protein in horses, is an inconsistent finding in pneumonia and is not significantly associated with survival. 1,[7][8][9] With the development of a hand-held meter for measurement of SAA concentration, there is an opportunity for practitioners in both hospital and ambulatory settings to conveniently and effectively monitor trends in horses with pneumonia. 10 The objectives of this study were to describe SAA concentration over the course of disease in a group of horses with naturally occurring bronchopneumonia and pleuropneumonia and to identify whether correlations exist between SAA concentration, rectal temperature, WBC, neutrophil count, and plasma concentration of fibrinogen.…”

mentioning

confidence: 99%

“…Seventeen of 18 horses had 1 or more abnormalities noted via thoracic ultrasonography at the time of admission including comet tail lesions, pulmonary consolidation, abscessation, or pleural effusion; findings were not documented for the remaining horse. Nine horses had co-morbidities including thrombophlebitis (1), laminitis (2), cholelithiasis/cholangiohepatitis (1), rhabdomyolysis (1), dysphagia (1), pharyngitis (1), tracheostomy (1), a tracheal stent(1), and a fracture of the second phalanx (1).…”

mentioning

confidence: 99%

See 4 more Smart Citations

Utility of serum amyloid A in monitoring clinical response to antimicrobial treatment in horses with bacterial pneumonia

Hepworth-Warren

Estell

Cowles

et al. 2023

Veterinary Internal Medicne

View full text Add to dashboard Cite

BackgroundSerum amyloid A (SAA) is a major acute phase protein in horses which could be a useful tool for assessing clinical response to treatment of bacterial pneumonia in adult horses.ObjectivesTo monitor SAA concentration in response to treatment and identify associations among SAA concentration, WBC and neutrophil counts, and fibrinogen in bacterial pneumonia in adult horses.AnimalsEighteen adult horses with bacterial pneumonia.MethodsProspective clinical study. Horses hospitalized with bacterial pneumonia were enrolled and SAA concentration and vital signs were assessed daily. SAA concentration was measured by a handheld meter. CBC and plasma fibrinogen were assessed on days 0, 1, and 2, then every 3 days until discharge. Data were not normally distributed and therefore were log transformed. Log‐transformed data were analyzed and comparisons were performed on LSMeans by the 2‐sided Student's t‐test at the 5% level of significance.ResultsGeometric mean SAA concentration on day 0 was 537 μg/mL (SE 383 μg/mL). Geometric mean SAA concentration decreased significantly over time (P = .0001), peaking at day 2 (geomean 1038 μg/mL, SE 261.7 μg/mL) and decreasing until discharge. Plasma concentration of fibrinogen (P = .06), neutrophil count (P = .48), and WBC count (P = .07) did not change significantly over time.Conclusions and Clinical ImportanceSAA concentration decreased significantly over the course of treatment and correlated with clinical improvement of pneumonia whereas fibrinogen, neutrophil, and WBC counts did not.

show abstract