Proteinopathies: Deciphering Physiology and Mechanisms to Develop Effective Therapies for Neurodegenerative Diseases

Chopra, Gouri; Shabir, Shabnam; Yousuf, Sumaira; Kauts, Simran; Bhat, Shahnawaz Ali; Mir, Ashiq H.; Singh, Mahendra P.

doi:10.1007/s12035-022-03042-8

Cited by 8 publications

(10 citation statements)

References 242 publications

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“…Acetylcholinesterase is a cholinergic system enzyme that governs physiological functions such as movement and memory [ 83 ]. By hydrolyzing acetylcholine into acetate and choline, it inhibits cholinergic neurotransmission across synapses [ 84 ]. In this experiment, it was observed that when the Drosophila larvae exposed to rotenone for 24 h showed a considerably significant ( p < 0.001) decrease in acetylcholinesterase activity compared to either DMSO or control, they had ~66.31% reduced AChE levels.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Potential of Green-Engineered ZnO Nanoparticles on Rotenone-Exposed D. melanogaster (Oregon R+): Unveiling Ameliorated Biochemical, Cellular, and Behavioral Parameters

Shabir,

Sehgal,

Dutta

et al. 2023

Antioxidants

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Nanotechnology holds significant ameliorative potential against neurodegenerative diseases, as it can protect the therapeutic substance and allow for its sustained release. In this study, the reducing and capping agents of Urtica dioica (UD), Matricaria chamomilla (MC), and Murraya koenigii (MK) extracts were used to synthesize bio-mediated zinc oxide nanoparticles (ZnO-NPs) against bacteria (Staphylococcus aureus and Escherichia coli) and against rotenone-induced toxicities in D. melanogaster for the first time. Their optical and structural properties were analyzed via FT-IR, DLS, XRD, EDS, SEM, UV–Vis, and zeta potential. The antioxidant and antimicrobial properties of the fabricated ZnO-NPs were evaluated employing cell-free models (DPPH and ABTS) and the well diffusion method, respectively. Rotenone (500 µM) was administered to Drosophila third instar larvae and freshly emerged flies for 24–120 h, either alone or in combination with plant extracts (UD, MC, an MK) and their biogenic ZnO-NPs. A comparative study on the protective effects of synthesized NPs was undertaken against rotenone-induced neurotoxic, cytotoxic, and behavioral alterations using an acetylcholinesterase inhibition assay, dye exclusion test, and locomotor parameters. The findings revealed that among the plant-derived ZnO-NPs, MK-ZnO NPs exhibit strong antimicrobial and antioxidant activities, followed by UD-ZnO NPs and MC-ZnO NPs. In this regard, ethno-nano medicinal therapeutic uses mimic similar effects in D. melanogaster by suppressing oxidative stress by restoring biochemical parameters (AchE and proteotoxicity activity) and lower cellular toxicity. These findings suggest that green-engineered ZnO-NPs have the potential to significantly enhance outcomes, with the promise of effective therapies for neurodegeneration, and could be used as a great alternative for clinical development.

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Section: Discussionmentioning

confidence: 99%

Therapeutic Potential of Green-Engineered ZnO Nanoparticles on Rotenone-Exposed D. melanogaster (Oregon R+): Unveiling Ameliorated Biochemical, Cellular, and Behavioral Parameters

Shabir,

Sehgal,

Dutta

et al. 2023

Antioxidants

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“…Neurotoxins are any compounds that can damage the central nervous system, along with the brain ( 80 ). The brain is particularly prone to OP toxicity, which disrupts the balance of oxidant and antioxidant components in neuronal cells ( 91 ). OPs have a strong pro-oxidant action that disrupts neuronal mitochondrial function, resulting in a variety of neurological disorders.…”

Section: Relationship Of the Toxicity Of Some Pesticides With Alterat...mentioning

confidence: 99%

Role of nutraceutical against exposure to pesticide residues: power of bioactive compounds

Sajad,

Shabir,

Singh

et al. 2024

Front. Nutr.

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Pesticides play a crucial role in modern agriculture, aiding in the protection of crops from pests and diseases. However, their indiscriminate use has raised concerns about their potential adverse effects on human health and the environment. Pesticide residues in food and water supplies are a serious health hazards to the general public since long-term exposure can cause cancer, endocrine disruption, and neurotoxicity, among other health problems. In response to these concerns, researchers and health professionals have been exploring alternative approaches to mitigate the toxic effects of pesticide residues. Bioactive substances called nutraceuticals that come from whole foods including fruits, vegetables, herbs, and spices have drawn interest because of their ability to mitigate the negative effects of pesticide residues. These substances, which include minerals, vitamins, antioxidants, and polyphenols, have a variety of biological actions that may assist in the body’s detoxification and healing of harm from pesticide exposure. In this context, this review aims to explore the potential of nutraceutical interventions as a promising strategy to mitigate the toxic effects of pesticide residues.

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“…Typically, cells avoid forming aggregates, or if they already exist, the cells destroy them in order to prevent any potentially harmful effects. 13 However, preservation of proteome stability is challenging once cells are exposed to certain environmental stressors. Viral infection is one such stressor whereby the viruses hijack the cellular machinery, alter proteostasis to allow replication and then leave the cell to infect other nearby cells ( Fig.…”

Section: Neurodegenerative Mechanisms Associated With Viral Infectionmentioning

confidence: 99%

Enterovirus infection and its relationship with neurodegenerative diseases

Sousa

Vieira

2023

Mem. Inst. Oswaldo Cruz

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Neurodegenerative diseases (NDs) are increasingly common, especially in populations with higher life expectancies. They are associated mainly with protein metabolism and structure changes, leading to neuronal cell death. Viral infections affect these cellular processes and may be involved in the etiology of several neurological illnesses, particularly NDs. Enteroviruses (EVs) frequently infect the central nervous system (CNS), causing neurological disease. Inflammation, disruption of the host autophagy machinery, and deregulation and accumulation/misfolding of proteins are the main alterations observed after infection by an EV. In this perspective, we discuss the most recent findings on the subject, examining the possible role of EVs in the development of NDs, and shedding light on the putative role played by these viruses in developing NDs.

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Proteinopathies: Deciphering Physiology and Mechanisms to Develop Effective Therapies for Neurodegenerative Diseases

Cited by 8 publications

References 242 publications

Therapeutic Potential of Green-Engineered ZnO Nanoparticles on Rotenone-Exposed D. melanogaster (Oregon R+): Unveiling Ameliorated Biochemical, Cellular, and Behavioral Parameters

Therapeutic Potential of Green-Engineered ZnO Nanoparticles on Rotenone-Exposed D. melanogaster (Oregon R+): Unveiling Ameliorated Biochemical, Cellular, and Behavioral Parameters

Role of nutraceutical against exposure to pesticide residues: power of bioactive compounds

Enterovirus infection and its relationship with neurodegenerative diseases

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