Abstract:Serine proteinase inhibitors, in the seeds of several Leguminosae from the Pantanal region (West Brazil), were studied using bovine trypsin, a digestive enzyme, Factor XIIa and human plasma kallikrein, two blood clotting factors. The inhibitors were purified from Enterolobium contortisiliquum (M(r) = 23,000), Torresea cearensis (M(r) = 13,000), Bauhinia pentandra (M(r) = 20,000) and Bauhinia bauhinioides (M(r) = 20,000). E. contortisiliquum inhibitor inactivates all three enzymes, whereas the T. cearensis inhi… Show more
“…Seed is used for perfume and soap (Record & Hess, 1972) Medical investigation Sampaio, Oliva, Tanaka, and Sampaio (1991) and Tanaka, Sampaio, Sampaio, and Oliva (1989) reported the inhibition of blood coagulation by factors in extracts from the seed of A. cearensis. Proteinase inhibitors are considered responsible for this effect.…”
“…Seed is used for perfume and soap (Record & Hess, 1972) Medical investigation Sampaio, Oliva, Tanaka, and Sampaio (1991) and Tanaka, Sampaio, Sampaio, and Oliva (1989) reported the inhibition of blood coagulation by factors in extracts from the seed of A. cearensis. Proteinase inhibitors are considered responsible for this effect.…”
“…This has been used by people for many years, especially for presenting hypoglycemic activity, a reported activity since the 1990s by several authors [1,2,3]. Another species that has shown scientific importance is the Bauhinia pentandra has been shown antiulcer activity4 and acts on the inhibition of coagulation factor XIIa [5,6]. The species Bauhinia pentandra (Bong.)…”
“…7 – 9 Another species that has shown scientific relevance is Bauhinia pentandra , which has demonstrated antiulcer activity, 10 and has an inhibitory effect on factor XIIa in the coagulation cascade. 11 , 12 …”
BackgroundThe search for new active compounds from the Brazilian flora has intensified in recent years, especially for new drugs with antibiotic potential. Accordingly, the aim of this study was to determine whether riachin has antibiotic activity in itself or is able to modulate the activity of conventional antibiotics.MethodsA non-cyanogenic cyanoglycoside known as riachin was isolated from Bauhinia pentandra, and was tested alone and in combination with three antibiotics (clindamycin, amikacin, and gentamicin) against multiresistant bacterial strains (Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus).ResultsRiachin did not show significant antibiotic activity when tested alone against any strain (P>0.05). However, when combined with conventional antibiotics, it showed drug-modifying activity against strains of S. aureus exposed to clindamycin (P<0.001) as well as against P. aeruginosa exposed to amikacin (P<0.001). Although riachin did not show direct antibiotic activity, it had synergistic activity when combined with amikacin or clindamycin. The mechanism of action of this synergism is under investigation.ConclusionThe results of this work demonstrate that some substances of natural origin can enhance the effectiveness of certain antibiotics, which means a substantial reduction in the drug dose required and possibly in consequent adverse events for patients.
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