Proteinase-inhibiting activity of an extract of Rumex acetosa L. against virulence factors of Porphyromonas gingivalis

Beckert, S; Hensel, Andreas

doi:10.1055/s-0033-1352210

Cited by 3 publications

(1 citation statement)

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“…Amongst them, polyphenolic plant bioactives (catechins and proanthocyanidins) were found to be effective inhibitors ( Okamoto et al., 2004 ; Beckert and Hensel, 2013 ). Other plant extracts demonstrating gingipain protease inhibition activities include Oryza sativa ( Taiyoji et al., 2013 ), Dodonaea viscosa ( Patel et al., 2013 ), Rumex acetosa L. ( Beckert and Hensel, 2013 ; Schmuch et al., 2015 ), Canavalia gladiata ( Nakatsuka et al., 2014 ), Rhododendron ferrugineum ( Löhr et al., 2015 ) and Limonium brasiliense ( de Oliveira Caleare et al., 2017 ). Limitation in most of these studies is the lack of information pertaining to the inhibitory mechanism of Rgp.…”

Section: Gingipain Rmentioning

confidence: 99%

Implications of Porphyromonas gingivalis peptidyl arginine deiminase and gingipain R in human health and diseases

Chow

Yam

Gunasekaran

et al. 2022

Front. Cell. Infect. Microbiol.

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Porphyromonas gingivalis is a major pathogenic bacterium involved in the pathogenesis of periodontitis. Citrullination has been reported as the underlying mechanism of the pathogenesis, which relies on the interplay between two virulence factors of the bacterium, namely gingipain R and the bacterial peptidyl arginine deiminase. Gingipain R cleaves host proteins to expose the C-terminal arginines for peptidyl arginine deiminase to citrullinate and generate citrullinated proteins. Apart from carrying out citrullination in the periodontium, the bacterium is found capable of citrullinating proteins present in the host synovial tissues, atherosclerotic plaques and neurons. Studies have suggested that both virulence factors are the key factors that trigger distal effects mediated by citrullination, leading to the development of some non-communicable diseases, such as rheumatoid arthritis, atherosclerosis, and Alzheimer’s disease. Thus, inhibition of these virulence factors not only can mitigate periodontitis, but also can provide new therapeutic solutions for systematic diseases involving bacterial citrullination. Herein, we described both these proteins in terms of their unique structural conformations and biological relevance to different human diseases. Moreover, investigations of inhibitory actions on the enzymes are also enumerated. New approaches for identifying inhibitors for peptidyl arginine deiminase through drug repurposing and virtual screening are also discussed.

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Section: Gingipain Rmentioning

confidence: 99%

Implications of Porphyromonas gingivalis peptidyl arginine deiminase and gingipain R in human health and diseases

Chow

Yam

Gunasekaran

et al. 2022

Front. Cell. Infect. Microbiol.

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Sorrel (Rumex acetosa L.): Not Only a Weed but a Promising Vegetable and Medicinal Plant

Korpelainen

Pietiläinen

2020

Bot. Rev.

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Sorrel (Rumex acetosa L.) is a perennial, dioecious herb occupying a variety of habitats. Sorrel has been utilized as a wild gathered plant for thousands of years and as a cultivated plant for centuries. Primarily roots but also other tissues have been used in folk remedies since ancient times. In recent investigations, different phytochemical and pharmacological activities of Rumex have been analyzed, and many bioactive compounds have been detected. Sorrel is also a tasty plant and its leaves are a good source of macronutrients and micronutrients. However, the presence of high levels of oxalic acid reduces the bioavailability of some minerals, especially calcium, when using uncooked plant parts. Further investigations on different sorrel compounds are needed to show their true effect. It is beneficial that sorrel is easily propagated and there are no serious insect or disease problems. A few types of R. acetosa seeds are presently available commercially, including wild types and a few cultivars.

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Recognition of leaves of different medicinal plant species using a robust image processing algorithm and artificial neural networks classifier

Azadnia

Kheiralipour

2021

Journal of Applied Research on Medicinal and Aromatic Plants

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Proteinase-inhibiting activity of an extract of Rumex acetosa L. against virulence factors of Porphyromonas gingivalis

Cited by 3 publications

References 0 publications

Implications of Porphyromonas gingivalis peptidyl arginine deiminase and gingipain R in human health and diseases

Implications of Porphyromonas gingivalis peptidyl arginine deiminase and gingipain R in human health and diseases

Sorrel (Rumex acetosa L.): Not Only a Weed but a Promising Vegetable and Medicinal Plant

Recognition of leaves of different medicinal plant species using a robust image processing algorithm and artificial neural networks classifier

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