2002
DOI: 10.1016/s0049-3848(02)00181-0
|View full text |Cite
|
Sign up to set email alerts
|

Protein Z influences the prothrombotic phenotype in Factor V Leiden patients

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

6
83
2
4

Year Published

2004
2004
2015
2015

Publication Types

Select...
5
2
2

Relationship

1
8

Authors

Journals

citations
Cited by 79 publications
(95 citation statements)
references
References 11 publications
6
83
2
4
Order By: Relevance
“…We recently described a P2Y 12 gene polymorphism associated with ADPinduced maximal platelet aggregation [3], the H2 haplotype being associated with a higher aggregation response in healthy subjects. Moreover, we found a significant association between the P2Y 12 H2 haplotype and peripheral vascular disease in a case-control study [4]. In view of the results presented by Leon et al, we hypothesized that the H1/H2 polymorphism could be associated with collagen-induced platelet aggregation response, basal TF expression in monocytes (TF mRNA), plasma…”
Section: )1mentioning
confidence: 51%
See 1 more Smart Citation
“…We recently described a P2Y 12 gene polymorphism associated with ADPinduced maximal platelet aggregation [3], the H2 haplotype being associated with a higher aggregation response in healthy subjects. Moreover, we found a significant association between the P2Y 12 H2 haplotype and peripheral vascular disease in a case-control study [4]. In view of the results presented by Leon et al, we hypothesized that the H1/H2 polymorphism could be associated with collagen-induced platelet aggregation response, basal TF expression in monocytes (TF mRNA), plasma…”
Section: )1mentioning
confidence: 51%
“…The PZdependent protease inhibitor in the presence of PZ causes fast inactivation of factor Xa. Recently, reduced circulating levels of PZ have been suggested to play a role in the occurrence of bleeding [2] and deep vein thrombosis [3,4], as well as primary aborts with unexplained early fetal loss [5]. However, these data have been disputed [6][7][8].…”
Section: R S a N T A C R O C E F C A P P U C C I * P D I P mentioning
confidence: 99%
“…ZPI also inhibits factor XIa efficiently independent of protein Z (3,4). The importance of ZPI and PZ as anticoagulant regulators of factor Xa and factor XIa is suggested by the prothrombotic phenotype of PZ knock-out mice and embryonic lethality of ZPI knock-out mice harboring the factor V Leiden mutation (5,6), consistent with the aggravated thromboembolic risk observed in factor V Leiden patients with PZ deficiency (7). Clinical studies concerning the relationship between ZPI/PZ levels and risk of venous thrombosis and thromboembolic diseases are often conflicting, although generally there are more reports supporting such association than those that do not (8,9).…”
Section: Protein Z-dependent Protease Inhibitor (Zpi)mentioning
confidence: 61%
“…11 Patients with homozygotic factor-V-disease mutation, however, combine low Protein-Z levels with an increased procoagulation potential. 12 These examples may shed some light on the ambivalent function of some factors in many coagulation defects caused by the inherent complexity of the regulation systems.…”
Section: Discussionmentioning
confidence: 99%