Protein vicinal thiols as intrinsic probes of brain redox states in health, aging, and ischemia
Timothy D. Foley,
Wen C. Huang,
Emily A. Petsche
et al.
Abstract:The nature of brain redox metabolism in health, aging, and disease remains to be fully established. Reversible oxidations, to disulfide bonds, of closely spaced (vicinal) protein thiols underlie the catalytic maintenance of redox homeostasis by redoxin enzymes, including thioredoxin peroxidases (peroxiredoxins), and have been implicated in redox buffering and regulation. We propose that non-peroxidase proteins containing vicinal thiols that are responsive to physiological redox perturbations may serve as intri… Show more
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