2009
DOI: 10.1007/s00221-009-1963-6
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Protein tyrosine phosphatases expression during development of mouse superior colliculus

Abstract: Protein tyrosine phosphatases (PTPs) are key regulators of different processes during development of the central nervous system. However, expression patterns and potential roles of PTPs in the developing superior colliculus remain poorly investigated. In this study, a degenerate primer-based reverse transcription-polymerase chain reaction (RT-PCR) approach was used to isolate seven different intracellular PTPs and nine different receptor-type PTPs (RPTPs) from embryonic E15 mouse superior colliculus. Subsequen… Show more

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Cited by 8 publications
(3 citation statements)
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“…Images were taken with a confocal laser‐scanning microscope LSM 510 META (Zeiss). Laser lines and emission filters were optimized with the Zeiss LSM Image Browser software . Tenascin‐C and 473HD immunoreactivity were analyzed using an ImageJ macro .…”
Section: Methodsmentioning
confidence: 99%
“…Images were taken with a confocal laser‐scanning microscope LSM 510 META (Zeiss). Laser lines and emission filters were optimized with the Zeiss LSM Image Browser software . Tenascin‐C and 473HD immunoreactivity were analyzed using an ImageJ macro .…”
Section: Methodsmentioning
confidence: 99%
“…During development, PTPs exhibit a distinct spatial pattern of expression and are implicated in axon growth and guidance in CNS (Bixby, 2000; Stoker, 2001). A number of PTPs display a distinct spatiotemporal regulation in the pre- and postnatal superior colliculus, which appears to correlate with neuronal proliferation, differentiation, axon innervation and arborization (Reinhard et al, 2009). The LAR subfamily is composed of three vertebrate homologs: LAR, PTPσ, and PTPδ, which share 66% amino acid identity in the full-length proteins and 84% identity in the catalytic domains.…”
Section: Receptor-mediated Inhibition By Cspgsmentioning
confidence: 99%
“…During development, PTPs exhibit a distinct spatial pattern of expression and are implicated in axon growth and guidance in the CNS(Bixby 2000; Stoker 2001). For example, a number of PTPs displayed a distinct spatiotemporal regulation in the pre- and postnatal superior colliculus, which appears to correlate with neuronal proliferation, differentiation, axon innervation and arborisation(Reinhard et al 2009). The LAR subfamily is composed of three vertebrate homologs: LAR, PTPσ, and PTPδ, which share 66% amino acid identity in the full-length proteins and 84% identity in the catalytic domains.…”
Section: Lar Subfamily Of Phosphatases As the Functional Receptors Fomentioning
confidence: 99%