Protein Transport in<i>Mycobacterium tuberculosis</i>

McDonough, Justin A.; Braunstein, Miriam

doi:10.1002/9783527611614.ch6

Cited by 1 publication

(1 citation statement)

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“…Together, these studies suggest that EspG confers specificity and guides Evolution of PE/PPE-associated virulence 905 Korotkova et al, 2014). While there has been intensive focus on T7S-mediated secretion, it is important to note that classical Sec pathway signal sequences have also been identified in some PE and PPE proteins (McDonough & Braunstein, 2008). Recent proteomic data indicate that predicted signal peptidase I sites in at least seven PE/PPE proteins are indeed cleaved, suggesting that these proteins may be exported via the general secretory pathway .…”

Section: Localization and Functional Studies Of Pe/ppe Proteinsmentioning

confidence: 99%

Phylogeny to function: PE/PPE protein evolution and impact on Mycobacterium tuberculosis pathogenicity

Fishbein

Wyk

Warren

et al. 2015

Molecular Microbiology

196

199

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SummaryThe pe/ppe genes represent one of the most intriguing aspects of the Mycobacterium tuberculosis genome. These genes are especially abundant in pathogenic mycobacteria, with more than 160 members in M. tuberculosis. Despite being discovered over 15 years ago, their function remains unclear, although various lines of evidence implicate selected family members in mycobacterial virulence. In this review, we use PE/PPE phylogeny as a framework within which we examine the diversity and putative functions of these proteins. We report on the evolution and diversity of the respective gene families, as well as the implications thereof for function and host immune recognition. We summarize recent findings on pe/ppe gene regulation, also placing this in the context of PE/PPE phylogeny. We collate data from several large proteomics datasets, providing an overview of PE/PPE localization, and discuss the implications this may have for host responses. Assessment of the current knowledge of PE/PPE diversity suggests that these proteins are not variable antigens as has been so widely speculated; however, they do clearly play important roles in virulence. Viewing the growing body of pe/ppe literature through the lens of phylogeny reveals trends in features and function that may be associated with the evolution of mycobacterial pathogenicity.

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Section: Localization and Functional Studies Of Pe/ppe Proteinsmentioning

confidence: 99%