volume 278, issue 33, P30835-30842 2003
DOI: 10.1074/jbc.m303846200
View full text

Abstract: Protein phosphatase-1 (PP1) plays an important role in the regulation of glycogen synthesis by insulin. Protein targeting to glycogen (PTG) enhances glycogen accumulation by increasing PP1 activity against glycogenmetabolizing enzymes. However, the specificity of PTG's effects on cellular dephosphorylation and glucose metabolism is unclear. Overexpression of PTG in 3T3-L1 adipocytes using a doxycycline-controllable adenoviral construct resulted in a 10 -20-fold increase in PTG levels and an 8-fold increase in…

Expand abstract