Protein synthesis during development and differentiation in the cellular slime mould <i>Dictyostelium discoideum</i>

Watts, Donald J.

doi:10.1042/bj2200001

Cited by 14 publications

(4 citation statements)

References 152 publications

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“…This review updates articles in the standard book on Dictyostelium development edited by W. F. Loomis (8) and complements recent reviews on receptors (9), chemotaxis (10), phototaxis (11), and control of gene expression during development (12,13). This review updates articles in the standard book on Dictyostelium development edited by W. F. Loomis (8) and complements recent reviews on receptors (9), chemotaxis (10), phototaxis (11), and control of gene expression during development (12,13).…”

Section: Summary and Perspectivesmentioning

confidence: 62%

CYCLIC AMP AND OTHER SIGNALS CONTROLLING CELL DEVELOPMENT AND DIFFERENTIATION IN DICTYOSTELIUM

Gerisch¹

1987

Annu. Rev. Biochem.

234

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Section: Summary and Perspectivesmentioning

confidence: 62%

CYCLIC AMP AND OTHER SIGNALS CONTROLLING CELL DEVELOPMENT AND DIFFERENTIATION IN DICTYOSTELIUM

Gerisch¹

1987

Annu. Rev. Biochem.

234

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“…The slime-molds, in particular Dictyostelium discoideum (Watts, 1984), provide a singularly dramatic example of such a phenomenon. The bacteria-munching, amoeboid form of D. discoideum contains approximately 10 M concentrations of both PP-InsP 5 and (PP) 2 -InsP 4 (Laussmann et al, 2000).…”

Section: Cellular Levels Metabolic Turnover and The Issue Of Comparmentioning

confidence: 99%

“…The bacteria-munching, amoeboid form of D. discoideum contains approximately 10 M concentrations of both PP-InsP 5 and (PP) 2 -InsP 4 (Laussmann et al, 2000). When the cells are starved of their bacteria food supply, the amoeboid cells aggregate, the first of a series of morphogenetic stages that culminate in the formation of a fruiting body (Watts, 1984). During the initial aggregation process, the levels of PP-InsP 5 and (PP) 2 -InsP 4 increase to 100 and 250 M, respectively (Laussmann et al, 2000;Luo et al, 2003).…”

Section: Cellular Levels Metabolic Turnover and The Issue Of Comparmentioning

confidence: 99%

Diphosphoinositol Polyphosphates: Metabolic Messengers?

Shears¹

2009

Mol Pharmacol

137

148

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The diphosphoinositol polyphosphates ("inositol pyrophosphates") are a specialized subgroup of the inositol phosphate signaling family. This review proposes that many of the current data concerning the metabolic turnover and biological effects of the diphosphoinositol polyphosphates are linked by a common theme: these polyphosphates act as metabolic messengers. This review will also discuss the latest proposals concerning possible molecular mechanisms of action of this intriguing class of molecules.The discovery of cyclic AMP Sutherland and Rall, 1958) introduced us to the concept of a "second messenger" (Robison et al., 1968): a diffusible molecule (or ion) that, in response to an extracellular stimulus, is rapidly generated at (or released from) a particular subcellular site and then regulates particular effector proteins within the cell so as to elicit a cellular response. Of course, evolution has a remarkable tendency to repeat a good idea, so many different second messengers are now known. The inositol phosphate family represents the convergence of several "good signaling ideas," most notably in their use of a recurring theme in the cell-signaling genre: phosphate groups. Phosphates have two especially prominent features that facilitate specificity of interactions between cell signaling entities. First, the bulky nature of the phosphate group imposes geometric constraints on ligand-protein and protein-protein interactions. Second, the phosphate's negative charge at physiological pH bestows specificity on its interactions with target proteins through multiple ionic and hydrogen bonds. The negative charges on the phosphate group also make soluble, phosphorylated molecules lipid-impermeant, so that they can be retained inside cells.Inositol offers several additional assets for a signaling molecule. It is chemically stable, it is small (hence it diffuses through cytosol quickly), and it is only a short synthetic offshoot from the glycolytic pathway (Sherman et al., 1977). There is also a functionally significant plane of symmetry across the 2/5-axis of the inositol ring (Fig. 1). That symmetry permits one inositol phosphate to imitate another's threedimensional phosphate recognition pattern when the orientation of the inositol ring changes in relation to the protein's ligand-binding site (Wilcox et al., 1994), although in addition the binding site itself has to be somewhat flexible . This phenomenon provides a molecular explanation for the metabolic promiscuity of certain inositol phosphate kinases (for review, see Shears, 2004), and it also facilitates functionally important metabolic interactions between differ-

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“…ELL surface adhesive molecules, such as glycosphingolipids C (1 9), glycosaminoglycans (22), and glycoproteins ( I , 32) have been implicated in a variety of the cellular events of metazoan organisms, including growth factor activity (5), lymphocyte recirculation (33), cell-cell recognition ( 1 I), cellular differentiation (39), and metastasis (30). It has also been suggested that cell surface adhesion molecules play a key role in regulating morphogenesis (1 3).…”

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confidence: 99%

Cell Adhesion in Trypanosoma: In Vitro Studies of the Interaction of Trypanosoma vivax with Immobilized Organic Dyes1

Fish

Nelson

Hirumi

1987

The Journal of Protozoology

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Certain bloodstream forms of Trypanosoma vivax have been shown to attach to Amicon Matrex Gel Green A dye beads in a manner similar to the in vivo binding of T. vivax to the inner surface of the tsetse fly proboscis. We now report an in vitro assay for trypanosome-bead attachment and show that only the 9,10-anthraquinone portion of the dye molecule is involved in the binding of trypanosomes to beads and that bead-bound dyes with similar structures also support binding to differing degrees. The binding is dependent upon the amount of dye on the beads and this, and other evidence, suggests that an array of dye molecules, rather than individual molecules, may be the actual recognition site. Various external effectors, including temperature, soluble protein-dye complexes, and serum of mice with chronic T. vivax infections, reduce trypanosome binding, indicating that at least one immunogenic trypanosome macromolecule is involved. The trypanosome-bead interaction mimics the in vivo binding to tsetse proboscis and warrants closer examination as a model of trypanosome cell adhesion in the tsetse fly.

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Protein synthesis during development and differentiation in the cellular slime mould Dictyostelium discoideum

Cited by 14 publications

References 152 publications

CYCLIC AMP AND OTHER SIGNALS CONTROLLING CELL DEVELOPMENT AND DIFFERENTIATION IN DICTYOSTELIUM

CYCLIC AMP AND OTHER SIGNALS CONTROLLING CELL DEVELOPMENT AND DIFFERENTIATION IN DICTYOSTELIUM

Diphosphoinositol Polyphosphates: Metabolic Messengers?

Cell Adhesion in Trypanosoma: In Vitro Studies of the Interaction of Trypanosoma vivax with Immobilized Organic Dyes1

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