Protein synthesis and degradation gene SNPs related to feed intake, feed efficiency, growth, and ultrasound carcass traits in Nellore cattle

Abstract

ABSTRACT.We looked for possible associations of SNPs in genes related to protein turnover, with growth, feed efficiency and carcass traits in feedlot Nellore cattle. Purebred Nellore bulls and steers (N = 290; 378 ± 42 kg body weight, 23 months ± 42 days old) were evaluated for daily feed intake, body weight gain (BWG), gross feed efficiency, feed conversion ratio, partial efficiency of growth, residual feed intake (RFI), ultrasound backfat, rump fat, and ribeye area. Genotypes were obtained for SNPs in the growth hormone receptor (GHR-1 and GHR-2); calpain (CAPN4751); calpastatin (UoGCAST); ubiquitin-conjugating enzyme 2I (UBE2I-1 and UBE2I-2); R3H domain containing 1 (R3HDM1-1, -2, -3, and -4), ring finger protein 19 (RNF19); proteasome 26S subunit, non-ATPase, 13 (PSMD13); ribosomal protein, large, P2 (RPLP2); and isoleucine-tRNA synthetase 2, mitochondrial (IARS2) genes. Allelic substitution, additive and dominant effects were tested and molecular breeding values were computed. CAPN4751, GHR-1 and -2, IARS2, R3HDM1-4, and UoGCAST were found to be normally segregating polymorphisms. Additive and dominance effects were observed on BWG, feed efficiency and carcass traits, although dominant effects predominated. Significant allelic substitution effects were observed for CAPN4751, GHR-1 and -2, and UoGCAST on BWG, gross feed efficiency, RFI, and carcass traits, under single-or multiple-marker analyses. Correlations between molecular breeding values and phenotypes were low, excepted for RFI, based on allelic substitution estimates obtained by stepwise linear regression. We conclude that SNPs in genes related to protein turnover are related to economically important traits in Nellore cattle.

Systems genetics and genome-wide association approaches for analysis of feed intake, feed efficiency, and performance in beef cattle

“…These trials were carried out in individual pens with either GrowSafe or Calan Gates for recording the feed intake. Further details about the animals, phenotypes, facilities, experimental diets, and management procedures are available in Santana et al (2012), Gomes et al (2013), and Alexandre et al (2015).…”

“…In all the experiments, animals were handled in accordance with the guidelines of the Brazilian College of Animal Experimentation (COBEA). Phenotypic data and DNA samples were taken from each of the experiments, which had been approved by the respective Ethics Committees for each study (Santana et al, 2012;Gomes et al, 2013;Alexandre et al, 2015).…”

Short Communication Genome-wide association with residual body weight gain in Bos indicus cattle

“…The data used in this study are a compilation of 11 different experiments, which were approved by their respective ethic committees (Gomes et al, 2013;Santana et al, 2013). Phenotypic and genotypic information from 720 steers and young Nellore bulls were used in this study.…”

A new approach for applied nutritional models: Computing parameters of dynamic mechanistic growth models using genome-wide prediction

“…The study described herein used a dataset obtained from experiments published elsewhere Gomes et al, 2013;Santana et al, 2012), whose authors report phenotype records and DNA samples from tests approved by their respective institutional animal ethics committee and by the cattle owners. All animals' procedures were undertaken within common management practices in beef cattle feedlot operations and in accordance with standard veterinary protocols.…”