Protein-Steroid Interactions and Their Role in the Transport and Metabolism of Steroids

Sandberg, Avery A.; Rosenthal, Hannah E.; Schneider, Sara L.; Slaunwhite, W. Roy

doi:10.1016/b978-1-4832-2903-4.50005-2

Cited by 63 publications

(35 citation statements)

References 83 publications

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“…The association constant for progesterone and transcortin in humans at 37°C is three times higher than that of cortisol [16]. The data presented suggest a similar relationship in the baboon and thus, may account for the higher percentage of progesterone binding (22%) than cortisol (10%) to transcortin.…”

Section: Discussionsupporting

confidence: 57%

Sex Hormone Binding Globulin and Transcortin in Human and Baboon Males

Karr

Kirdani

Murphy

et al. 1978

Archives of Andrology

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TeBG and transcortin were identified in serum from adult male baboons. TeBG values were higher than the TeBG concentration in adult men. The relative competitive abilities of three natural steroids, a synthetic androgen and two synthetic estrogens, for binding sites on TeBG occupied by radioactive DHT were compared. At a 10-fold molar excess, using both baboon and human TeBG, DHT and T were the most effective competitors; EZ was intermediate and DES a very poor one. Using gel filtration, the transcortin concentrations (mgiL) in two baboons were 16.8 and 27.4; the normal range for men is 23-45, The serum transcortin value of a third baboon, determined by equilibrium dialysis, was 0.41 pMIL ( 2 1 3 mgiL). Competition studies, using both techniques, showed that progesterone has a slightly higher affinity for baboon transcortin than cortisol and that a synthetic progestin does not bind to transcortin. Plasma binding capacity for synthetic steroids should be tested before they are used for studies on specific tissue receptors contaminated with serum.

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Section: Discussionsupporting

confidence: 57%

Sex Hormone Binding Globulin and Transcortin in Human and Baboon Males

Karr

Kirdani

Murphy

et al. 1978

Archives of Andrology

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“…These findings may be related to recent observations that transcortin, a corticosteroid-binding globulin found in plasma, has a high affinity for pro¬ gesterone which at 37°C may be bound more strongly than cortisol (Sandberg, Rosenthal, Schneider & Slaunwhite, 1966;Seal & Doe, 1966;Gala & Westphal, 1967). Moreover in the guinea-pig there is a marked rise in the amount of circulating transcortin during pregnancy (Seal & Doe, 1966;Gala & Westphal, 1967), which corresponds closely with the rise in plasma pro¬ gesterone (around Day 20) observed by Heap et al (1967).…”

supporting

confidence: 62%

“…Taken with those of Seal & Doe (1966), Sandberg et al (1966 and Gala & Westphal (1967), the results in Table 1 …”

mentioning

confidence: 99%

“…It may be assumed from the results that the placenta, and possibly placental oestrogens (Deanesly, 1960), are actively concerned in the change in rate of progesterone metabolism. In some species, but not all, oestrogen administration stimulates the production Plasma progesterone in the pregnant guinea-pig 341 of transcortin (Sandberg et al, 1966;Seal & Doe, 1966) In all normal and hysterectomized females and in males with implanted tablets, plasma progesterone levels have remained low. Other aspects of these experiments will be described elsewhere.…”

mentioning

confidence: 99%

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The Increase in Plasma Progesterone Levels in the Pregnant Guinea-Pig and Its Possible Significance

Heap¹,

Deanesly²

1967

Reproduction

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“…These serum 'receptors' are relatively nonspecific, binding molecules which vary widely in structure and biological activity. Corticosterone-binding globulin (CBG) binds cortisol, corticosterone and progesterone [15]. Thyroxine-binding globulin has strong affinity with several organic dyes in addition to thyroxine and triiodothyronine [ 18].…”

Section: Discussionmentioning

confidence: 99%