2022
DOI: 10.1101/2022.02.17.480818
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Protein Stability Changes upon Point Mutations Identified with a Gaussian Network Model Simulating Protein Unfolding Behavior

Abstract: Understanding the effects of missense mutations on protein stability is a widely acknowledged significant biological problem. Genomic missense mutations may alter one or more amino acids leading to increased or decreased stability of the encoded proteins. In this study, we propose a novel approach - Protein Stability Prediction with a Gaussian Network Model (PSP-GNM) to study the effect of single amino acid substitutions on protein stability. Specifically, PSP-GNM employs a coarse-grained Gaussian Network Mode… Show more

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