Protein spectra and phospholipid composition of acetylcholine receptor-rich membrane from skeletal muscles of sensitized rats

Ado, A. D.; Stomakhina, N. V.; Tuluevskaya, L. M.; Fedoseeva, V. N.

doi:10.1007/bf00806320

Cited by 6 publications

(9 citation statements)

References 7 publications

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“…The mechanisms of these changes primarily involve the excitatory processes in the muscle fi ber membrane [1]. In vitro experiments on slow and fast skeletal muscles from mouse leg confi rmed this suggestion.…”

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confidence: 52%

Possible Mechanisms for the Effect of Protein Sensitization on Functional Properties of the Isolated m. soleus and m. EDL from Mice

et al. 2011

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We studied possible involvement of ATP in the influence of protein sensitization on contractile function and non-quantum secretion in the end-plate of isolated skeletal muscles from mouse leg. The dynamic vector of muscle contraction force was shown to correlate with changes in non-quantum secretion of acetylcholine under various conditions of experimental pathology. However, the degree of these changes was lower in sensitized animals. It can be hypothesized that the ATP-induced variability in functional properties of slow muscles during protein sensitization reflects the development of resistance to external loads. The adaptive changes in fast muscles during protein sensitization are not associated with the ATP-mediated mechanisms of excitation.

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confidence: 52%

Possible Mechanisms for the Effect of Protein Sensitization on Functional Properties of the Isolated m. soleus and m. EDL from Mice

et al. 2011

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“…Sensitization-induced changes in muscle fibers probably concern the outer membrane [1], electron-mechanical coupling [3], or contractile protein system [5]. Variations in contractile properties of mouse leg muscles during PS reflect the complexity of changes in SM under conditions of immunobiological reconstruction of the organism.…”

Section: Resultsmentioning

confidence: 99%

“…Opposite changes in functional properties of fast and slow muscles from mouse leg during protein sensitization are related to choline-mediated excitation of the muscle fiber membrane. Our results suggest that changes in contractile function of skeletal muscles during protein sensitization are associated with variations in choline-mediated excitation of the muscle fiber membrane and modification of electromechanical coupling.Immunobiological reconstruction of the organism is accompanied by changes in morphofunctional characteristics of skeletal muscles (SM) in warm-blooded animals [1]. Contractile function of isolated SM was evaluated in allergic guinea pigs.…”

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confidence: 99%

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Possible Mechanisms for the Effect of Protein Sensitization on Contractile Function of Fast and Slow Muscles in Mice

2009

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We studied the mechanisms underlying the effect of immunobiological reorganization of the organism on contractile function of isolated skeletal muscles from mouse leg (fast muscle, m. extensor digitorum longus; and slow muscle, m. soleus). Protein sensitization was accompanied by changes in contractile properties of fast and slow skeletal muscles. These changes were differently directed in muscles with various phenotypes. The force of carbachol-induced contraction (cholinergic agonist) increased in the slow muscle, but decreased in the fast muscle. The direction of changes in the force of carbachol-induced contractions under conditions of protein sensitization in skeletal muscles correlates with changes in non-quantal secretion of acetylcholine in the endplate (H-effect). Opposite changes in functional properties of fast and slow muscles from mouse leg during protein sensitization are related to choline-mediated excitation of the muscle fiber membrane. Our results suggest that changes in contractile function of skeletal muscles during protein sensitization are associated with variations in choline-mediated excitation of the muscle fiber membrane and modification of electromechanical coupling.

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“…Interestingly, the immunobiological reorganization of homeothermic organisms is also accompanied by changes in morphofunctional condition of SM (Ado et al 1984). It has previously been shown that ovalbumin-induced sensitization (OS), which is a widely accepted model of allergy, induced changes of contractile properties of slow and 'mixed-type' SM in guinea-pigs (Akhmedzyanov & Filippov, 1986).…”

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confidence: 99%

Ovalbumin‐induced sensitization affects non‐quantal acetylcholine release from motor nerve terminals and alters contractility of skeletal muscles in mice

Teplov

Гришин²,

Mukhamedyarov³

et al. 2009

Experimental Physiology

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Skeletal muscles play key roles in the development of various pathologies, including bronchial asthma and several types of auto-immune disorders, e.g. polymyositis. Since most of these maladies have an immunological/allergic element, this paper is devoted to assessing the impact of immunobiological reorganization on the functional properties of isolated skeletal muscles in mice. A combination of two methods (myography and electrophysiology) was used to evaluate extensor digitorum longus (EDL) and diaphragmatic muscle (DM) in this regard. Conventional myographic technique showed that ovalbumin-induced sensitization (OS) produced different changes in the contractile properties of EDL and DM. The amplitudes of carbachol (CCh)-induced contractions increased in DM but decreased in EDL. Those changes were inversely related to OS-mediated changes of non-quantal acetylcholine (ACh) release intensity within the muscle endplate, as shown by the electrophysiologically measured H-effect. These results clearly show that OS-mediated changes of non-quantal ACh release alter the functional properties of postjunctional ACh receptors and therefore contribute to the disturbance of CCh-induced contractility of skeletal muscles. Other mechanisms of OS-mediated changes of skeletal muscle contractility are also proposed and discussed.

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Protein spectra and phospholipid composition of acetylcholine receptor-rich membrane from skeletal muscles of sensitized rats

Cited by 6 publications

References 7 publications

Possible Mechanisms for the Effect of Protein Sensitization on Functional Properties of the Isolated m. soleus and m. EDL from Mice

Possible Mechanisms for the Effect of Protein Sensitization on Functional Properties of the Isolated m. soleus and m. EDL from Mice

Possible Mechanisms for the Effect of Protein Sensitization on Contractile Function of Fast and Slow Muscles in Mice

Ovalbumin‐induced sensitization affects non‐quantal acetylcholine release from motor nerve terminals and alters contractility of skeletal muscles in mice

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