Protein S100β in Late-Pregnancy Fetuses with Low Birth Weight and Abnormal Cerebroplacental Ratio

Morales‐Roselló, José; Khalil, Asma; Alba-Redondo, Amparo; Martinez-Triguero, Luisa; Akhoundova, Farida; Marín, Alfredo Perales; Thilaganathan, B.

doi:10.1159/000445114

Cited by 7 publications

(4 citation statements)

References 37 publications

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“…[6][7][8][9][10][11] Accordingly, improved detection of FGR has been identified as 1 of the top-10 interventions needed to reduce the global burden of stillbirth. 12 Although various tools are available to screen for FGR, including maternal obstetric history 13,14 and serum markers, [15][16][17][18][19][20][21] the most commonly screening approach is through sonographic fetal weight estimation to detect fetuses that are small for gestational age (SGA), defined empirically as an estimated fetal weight (EFW) <10th percentile for gestational age. [22][23][24][25][26] This approach, however, has a high false-positive rate for FGR, as the majority of SGA fetuses are healthy constitutionally small fetuses rather than growth restricted.…”

Section: Introductionmentioning

confidence: 99%

Fetal growth velocity and body proportion in the assessment of growth

Hiersch

Melamed

2018

American Journal of Obstetrics and Gynecology

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Fetal growth restriction implies failure of a fetus to meet its growth potential and is associated with increased perinatal mortality and morbidity. Therefore, antenatal detection of fetal growth restriction is of major importance in an attempt to deliver improved clinical outcomes. The most commonly used approach towards screening for fetal growth restriction is by means of sonographic fetal weight estimation, to detect fetuses small for gestational age, defined by an estimated fetal weight <10th percentile for gestational age. However, the predictive accuracy of this approach is limited both by suboptimal detection rate (as it may overlook non-small-for-gestational-age growth-restricted fetuses) and by a high false-positive rate (as most small-for-gestational-age fetuses are not growth restricted). Here, we review 2 strategies that may improve the diagnostic accuracy of sonographic fetal biometry for fetal growth restriction. The first strategy involves serial ultrasound evaluations of fetal biometry. The information obtained through these serial assessments can be interpreted using several different approaches including fetal growth velocity, conditional percentiles, projection-based methods, and individualized growth assessment that can be viewed as mathematical techniques to quantify any decrease in estimated fetal weight percentile, a phenomenon that many care providers assess and monitor routinely in a qualitative manner. This strategy appears promising in high-risk pregnancies where it seems to improve the detection of growth-restricted fetuses at increased risk of adverse perinatal outcomes and, at the same time, decrease the risk of falsely diagnosing healthy constitutionally small-for-gestational-age fetuses as growth restricted. Further studies are needed to determine the utility of this strategy in low-risk pregnancies as well as to optimize its performance by determining the optimal timing and interval between exams. The second strategy refers to the use of fetal body proportions to classify fetuses as either symmetric or asymmetric using 1 of several ratios; these include the head circumference to abdominal circumference ratio, transverse cerebellar diameter to abdominal circumference ratio, and femur length to abdominal circumference ratio. Although these ratios are associated with small for gestational age at birth and with adverse perinatal outcomes, their predictive accuracy is too low for clinical practice. Furthermore, these associations become questionable when other, potentially more specific measures such as umbilical artery Doppler are being used. Furthermore, these ratios are of limited use in determining the etiology underlying fetal smallness. It is possible that the use of the 2 gestational-age-independent ratios (transverse cerebellar diameter to abdominal circumference and femur length to abdominal circumference) may have a role in the detection of mild-moderate fetal growth restriction in pregnancies without adequate dating. In addition, despite their limited predictive accuracy, t...

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Section: Introductionmentioning

confidence: 99%

Fetal growth velocity and body proportion in the assessment of growth

Hiersch

Melamed

2018

American Journal of Obstetrics and Gynecology

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“…Deterioration in placental function during pregnancy results in compensatory hemodynamic changes in the fetus, with increased blood flow to the brain and other essential organs. This redistribution of cardiac output is typically seen in small‐for‐gestational‐age fetuses, or indeed, any fetus that fails to reach its growth potential regardless of gestation, and is associated with an increased risk of adverse perinatal and long‐term neurodevelopmental outcomes.…”

Section: Introductionmentioning

confidence: 99%

Magnitude of change in fetal cerebroplacental ratio in third trimester and risk of adverse pregnancy outcome

Flatley

Greer

Kumar

2017

Ultrasound in Obstet & Gyne

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“…Excessive production of S100β by glial cells may even lead to increased neuroinflammation and neurological dysfunction. Elevation of S100β was related to central nervous system injury (Yan et al, 2014) and poor outcome following brain injury (Morales-Rosello et al, 2017). In this study, the qRT-PCR results showed that the S100β mRNA level in the telencephalon was raised markedly in the fetal rats of the fatigue group.…”

Section: Discussionmentioning

confidence: 99%

Effects of Pregnant Fatigue on the Development of Offspring in Rats

Bai

Yan

et al. 2022

Biological Research For Nursing

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Aim To explore the correlation between pregnant fatigue and intrauterine physical and neural development of offspring in rats. Methods Sprague-Dawley pregnant rats were randomly divided into a normal control group, a mild fatigue group (stand in water for 6 hours/day), and a severe fatigue group (stand in water for 15 h/day). The levels of lactic acid, 5-Hydroxytryptamine and Interleukin-6 in cardiac serum of rats were used to evaluate the fatigue. The expression of S100β in the telencephalon, Insulin-like growth factor-1 (IGF-1) in the liver and Cyclooxygenage-2 (COX-2) in the small intestine tissues of fetal rats were examined. Frozen sections were taken from the telencephalon of rat pups to observe morphological changes in the hippocampal primordium. Results Pregnant fatigue led to a decrease in food intake ( F = 37.586, p = 0.000) and water intake ( F = 23.608, p = 0.000) in rats. The IGF-1 mRNA expression of fetal rats in the severe fatigue group was lower than that in the control group ( p = 0.0003). The expression of S100β mRNA ( p = 0.000) and COX-2 mRNA ( p = 0.0002) of fetal rats were higher in the severe fatigue group than in the control group. HE staining of the telencephalon of fetal rats in the pregnant fatigue group revealed sparse and irregular cell arrangement and increased gaps in the hippocampal primordial site. Conclusion Pregnant fatigue rats had both physical fatigue and mental fatigue. Fatigue during pregnancy affects physical development and neurodevelopment of offspring. Further research should elucidate the mechanisms of pregnant fatigue and its effects on offspring.

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Protein S100β in Late-Pregnancy Fetuses with Low Birth Weight and Abnormal Cerebroplacental Ratio

Cited by 7 publications

References 37 publications

Fetal growth velocity and body proportion in the assessment of growth

Fetal growth velocity and body proportion in the assessment of growth

Magnitude of change in fetal cerebroplacental ratio in third trimester and risk of adverse pregnancy outcome

Effects of Pregnant Fatigue on the Development of Offspring in Rats

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