Protein Restriction and Body Composition in Renal Disease

Eyre, Sintra; Attman, Per‐Ola

doi:10.1053/j.jrn.2007.08.006

Cited by 12 publications

(8 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most studies analyzed the effect of low protein diet on body composition focused on middle-aged patients. These studies indicated that low protein diet did not have adverse effects on body composition despite patients usually had weight loss in the first six months then recovered eventually 18 , 19 . With constant BMI, body fat percentage increased with aging 20 .…”

Section: Discussionmentioning

confidence: 93%

Effects of Diet Intervention on Body Composition in the Elderly with Chronic Kidney Disease

Hung¹,

Chiou²,

Wu³

et al. 2017

Int. J. Med. Sci.

View full text Add to dashboard Cite

Objective: It has been uncertain that low protein diet for patients with chronic kidney disease (CKD) may predispose to malnutrition. The study aimed to investigate the effects of low protein diet on body composition of CKD patients and analyze the influence of age.Methods: Patients with glomerular filtration rate less than 45 mL/min/1.73m2 including 103 elderly (70.7 ± 6.9 years old) and 56 non-elderly (49.8 ± 9.1 years old) CKD patients were enrolled. All patients were educated by dietitians to take low protein diet and were followed up regularly every three months. Their demographic data, underlying disease and body mass index (BMI) were reviewed and recorded. Results of body composition measurement and laboratory tests were collected every three months for one year.Results: At baseline, the distribution of body composition was similar in non-elderly patients between non-low and low protein groups. In the elderly, patients in low protein group had higher fat and lower muscle percentage. In one-year follow-up, non-elderly patients did not present significant changes in their BMI, serum albumin level and body compositions in both protein groups. Non-low protein group in elderly patients had significant decrease in BMI and estimated glomerular filtration rate (eGFR) after 12 months (both p< 0.05). Determination in body composition showed decrease in fat and increase in muscle component. In low protein group, their BMI was decreased and eGFR was not influenced. Fat component was decreased and muscle percentage was increased in one-year follow-up.Conclusions: In elderly CKD patients, low protein diet maintained good nutritional status and muscle mass was preserved.

show abstract

Section: Discussionmentioning

confidence: 93%

Effects of Diet Intervention on Body Composition in the Elderly with Chronic Kidney Disease

Hung¹,

Chiou²,

Wu³

et al. 2017

Int. J. Med. Sci.

View full text Add to dashboard Cite

show abstract

“…reported that after an initial decrease, lean body mass stabilized at 6 months and then increased significantly from 6 to 24 months; no significant change was observed for total fat mass . A recent review analyzing 14 studies, which included 666 patients on sVLPD, confirmed that, in all but two studies, this diet was not associated with deterioration in body composition . Fifteen years earlier, Walser had already concluded that “rather than causing malnutrition, sVLPD prevents it” .…”

Section: Is Svlpd Safe?mentioning

confidence: 99%

Do Ketoanalogues Still Have a Role in Delaying Dialysis Initiation in CKD Predialysis Patients?

Aparicio

Bellizzi

Chauveau

et al. 2013

Seminars in Dialysis

View full text Add to dashboard Cite

Early versus later start of dialysis is still a matter of debate. Low-protein diets have been used for many decades to delay dialysis initiation. Protein-restricted diets (0.3-0.6 g protein/kg/day) supplemented with essential amino acids and ketoanalogues (sVLPD) can be offered, in association with pharmacological treatment, to motivated stage 4-5 chronic kidney disease (CKD) patients not having severe comorbid conditions; they probably represent 30-40% of the concerned population. A satisfactory adherence to such dietary prescription is observed in approximately 50% of the patients. While the results of the studies on the effects of this diet on the rate of progression of renal failure remain inconclusive, they are highly significant when initiation of dialysis is the primary outcome. The correction of uremic symptoms allows for initiation of dialysis treatment at a level of residual renal function lower than that usually recommended. Most of the CKD-associated complications of cardiovascular and metabolic origin, which hamper both lifespan and quality of life, are positively influenced by the diet. Lastly, with regular monitoring jointly assumed by physicians and dietitians, nutritional status is well preserved as confirmed by a very low mortality rate and by the absence of detrimental effect on the long-term outcome of patients once renal replacement therapy is initiated. On account of its feasibility, efficacy and safety, sVLPD deserves a place in the management of selected patients to safely delay the time needed for dialysis.

show abstract

“…We used a regimen of low protein diet, with high biologic value in our protocol. The use of low protein diet, high biologic value proteins, and special formula, is one of the methods that could potentially alleviate the need for RRT in predialysis state (4)(5)(6). Low protein diet with the addition of Acacia gum (1 g/kg/day) is another regimen that has recently been reported to be a successful alternative to dialysis for some ESRD patients (13,14).…”

Section: Discussionmentioning

confidence: 99%

“…The potential benefit of low protein diets for uremic patients has long been debated. Diet modification in uremia should relieve uremic symptoms, correct some of the complications seen in kidney failure, and preserve or improve the nutritional state of patients (4)(5)(6). Prebiotics on the other hand, as a non-digestible food beneficially affects the host by selectively stimulating the growth and /or activity of one or a limited number of bacteria (usually bifidobacteria and lactobacilli) in the colon and thus improves host health (7)(8)(9).…”

mentioning

confidence: 99%

Dialysis Free Protocol for Some End Stage Renal Disease Patients (Khosroshahi Protocol)

Khosroshahi

Kalantar‐Zadeh

2012

FFHD

View full text Add to dashboard Cite

ABSTRACT:Background: The number of patients with End Stage Renal Disease (ESRD) is growing annually around the world. Provision of renal replacement therapy in the form of dialysis and transplant is relatively expensive. Recent studies have shown no survival benefit of early initiation of dialysis. Given recent outcome data of the timing of dialysis treatment and the expenses and logistics of hemodialysis procedure have stimulated research on alternative strategies. The aim of this study is to introduce another type of renal replacement therapy for selective patients with advanced chronic kidney disease (CKD). Methods:In a case series we used a so-called "dialysis free protocol" consisting of a low protein diet, uremic toxin adsorbents, and prebiotics for selective ESRD patients who had dialysis access constraints or did not agree placement of hemodialysis vascular access or peritoneal dialysis catheter.Findings: clinical and biochemical results of this study showed that these patients were not deteriorating during the study period and Blood Urea Nitrogen (Bun) & serum creatinin levels were not elevated in these months. Participating patients were relatively well throughout the study without signs of florid uremia and without a need for emergent or urgent dialysis. Conclusion:We conclude that our proposed dialysis free protocol reduces the need for dialysis treatment at least transiently. Whether this protocol can reduce the need for dialysis treatment requires additional studies.

show abstract

Protein Restriction and Body Composition in Renal Disease

Cited by 12 publications

References 29 publications

Effects of Diet Intervention on Body Composition in the Elderly with Chronic Kidney Disease

Effects of Diet Intervention on Body Composition in the Elderly with Chronic Kidney Disease

Do Ketoanalogues Still Have a Role in Delaying Dialysis Initiation in CKD Predialysis Patients?

Dialysis Free Protocol for Some End Stage Renal Disease Patients (Khosroshahi Protocol)

Contact Info

Product

Resources

About