Protein‐resistant surfaces prepared by PEO‐containing block copolymer surfactants

Lee, Jin Ho; Kopeček, Jindřich; Andrade, Joseph D.

doi:10.1002/jbm.820230306

Cited by 464 publications

(292 citation statements)

References 36 publications

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“…PEG molecules in water are in a liquid-like state, with rapid movement and a large excluded volume, with high PEG content surfaces providing the greatest steric interference 35 . This is also applicable to the PEGT:PBT substrates synthesized and studied herein, and was examined using PEG length and weight ratio.…”

Section: Discussionmentioning

confidence: 99%

Modulation of Chondrocyte Phenotype for Tissue Engineering by Designing the Biologic−Polymer Carrier Interface

et al. 2006

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Therapeutic strategies based on cell and tissue engineering can be advanced by developing material substrates that effectively interrogate the biological compartment, with or without, the complimentary local release of growth factors. Poly(ether ester) segmented copolymers were engineered as model material systems to elucidate the interfacial molecular events that govern the function of adhered cells. Surface chemistry was modulated by varying poly(ethylene glycol) (PEG) length and mole fraction with poly(butylene terephthalate) (PBT), leading to differential competitive protein adsorption of fibronectin and vitronectin from serum, and consequently to different cell attachment modes. Adhesion within the hydrogellike milieu of longer surface PEG was mediated via binding to the CD44 transmembrane receptor, rather than the RGD-integrin mechanism, whereas greater substrate-bound fibronectin resulted in cell adhesion via integrins. These adhesion modalities differentially impacted morphological cell phenotype (spread or spheroid) and the subsequent expression of mRNA transcripts (collagen types II, I) characteristic of phenotypically differentiated or dedifferentiated chondrocytes, respectively. These results demonstrate that materials can be designed to directly elicit the membrane bound receptor apparatus desired for downstream cellular response, without requiring exogenous biological growth factors to enable differentiated potential.

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Section: Discussionmentioning

confidence: 99%

Modulation of Chondrocyte Phenotype for Tissue Engineering by Designing the Biologic−Polymer Carrier Interface

et al. 2006

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“…Such inert coatings have been identified for a number of well-defined surfaces in short term, single species assays. Especially ethylene glycol (EG) x -containing coatings have been used in the biomedical area [21][22][23][24] and have recently been investigated with respect to their marine anti-fouling potential [25][26][27][28][29][30][31][32][33]. However, the degradation of the ethylene-glycol-containing chemistries makes them unsuitable for long-term antifouling applications [34,35].…”

Section: Biofouling Research: the Quest For Environmentallymentioning

confidence: 99%

Surface Sensing and Settlement Strategies of Marine Biofouling Organisms

Rosenhahn

Sendra

2012

Biointerphases

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This review article summarizes some recent insights into the strategies used by marine organisms to select surfaces for colonization. While larger organisms rely on their sensory machinery to select surfaces, smaller microorganisms developed less complex but still effective ways to probe interfaces. Two examples, zoospores of algae and barnacle larvae, are discussed and both appear to have build-in test mechanisms to distinguish surfaces with different physicochemical properties. Some systematic studies on the influence of surface cues on exploration, settlement and adhesion are summarized. The intriguing notion that surface colonization resembles a parallelized surface sensing event is discussed towards its complementarity with conventional surface analytical tools. The strategy to populate only selected surfaces seems advantageous as waves, currents and storms constantly challenge adherent soft and hard fouling organism.

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“…[49] An appealing strategy consists of surface functionalization using proteinand cell-resistant polymers. Over the last decade, several protein-resistant polymers have been developed building on different architectures such as, for example, polyethyleneglycol (PEG), [50][51][52] polyglycerols [53] and peptoids. [54] Forl ong-term applications, however, their attachment on surfaces becomes crucial, as detachment of the polymers directly impairs their function.…”

Section: Passive Inhibition Of Biofoulingmentioning

confidence: 99%

Cyanobacterial Natural Products for the Inhibition of Biofilm Formation and Biofouling

Gademann¹

2007

Chimia

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Biofouling is defined by the non-specific attachment of biological material (proteins, carbohydrates, prokaryotic cells and higher organisms) to surfaces upon their exposuret oa ny biological fluid. Biofouling is a serious problem in many areas ranging from marine technology,nuclear power plants, dentistry,food processing to biomedical implants. This process can be addressed either actively by chemical compounds inhibiting growth, settlement or biofilm formation, or passively by generating repellent or resistant surfaces. This highlight article gives an overview over different secondary metabolites from cyanobacteria useful in this context. Acandidate for active antifouling is nostocarboline, acarboline alkaloid from Nostoc.Ithas distinct and powerful activities against both prokaryotic and eukaryotic photosynthetic organisms. This compound is acandidate for the replacement of toxic tributyltin (TBT) antifouling coatings. Another passive strategy is presented utilizing the strong binding of anachelin to metal oxide surfaces. This anchor binds polyethyleneglycol (PEG) efficiently to surfaces and renders TiO 2 protein resistant. This anchor displays superior properties when compared to dopamine or DOPA, ak ey constituent in mussel adhesive proteins (MAP). Implications for biomaterials design arediscussed.

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Protein‐resistant surfaces prepared by PEO‐containing block copolymer surfactants

Cited by 464 publications

References 36 publications

Modulation of Chondrocyte Phenotype for Tissue Engineering by Designing the Biologic−Polymer Carrier Interface

Modulation of Chondrocyte Phenotype for Tissue Engineering by Designing the Biologic−Polymer Carrier Interface

Surface Sensing and Settlement Strategies of Marine Biofouling Organisms

Cyanobacterial Natural Products for the Inhibition of Biofilm Formation and Biofouling

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