2021
DOI: 10.1186/s13071-020-04574-5
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Protein regulation strategies of the mouse spleen in response to Babesia microti infection

Abstract: Background Babesia is a protozoan parasite that infects red blood cells in some vertebrates. Some species of Babesia can induce zoonoses and cause considerable harm. As the largest immune organ in mammals, the spleen plays an important role in defending against Babesia infection. When infected with Babesia, the spleen is seriously injured but still actively initiates immunomodulatory responses. Methods To explore the molecular mechanisms underlying… Show more

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Cited by 10 publications
(10 citation statements)
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“…The spleen performs numerous immune functions and participates in hematopoiesis, blood-borne pathogen clearance, and erythrocyte homeostasis ( Xue et al, 2021 ). Macrophages in the spleen serve mostly to filter blood and phagocytose aging red blood cells (RBC).…”
Section: Introductionmentioning
confidence: 99%
“…The spleen performs numerous immune functions and participates in hematopoiesis, blood-borne pathogen clearance, and erythrocyte homeostasis ( Xue et al, 2021 ). Macrophages in the spleen serve mostly to filter blood and phagocytose aging red blood cells (RBC).…”
Section: Introductionmentioning
confidence: 99%
“…In leishmaniasis, the nuclear factor kappa-light-chain enhancer of activated B cells (NF-kB) signaling pathway and pro-apoptotic protein kinase C delta (PKC-δ) were downregulated, while inhibition of caspase-3 activation prevented L. aethiopica spreading ( 42 ). On the other hand, STAT-5 is also related to promote T cell proliferation and differentiation with immune-related proteins, while spleen continued to initiate immune responses to combat the infection of B. microti ( 43 ).…”
Section: Discussionmentioning
confidence: 99%
“…165031). The procedures of animal feeding and material collection were completed in the second level Biosafety Laboratory of the fourth hospital of Hebei Medical University [ 26 ].…”
Section: Methodsmentioning
confidence: 99%