Protein pulse feeding improves protein retention in elderly women

Arnal, M.; Mosoni, Laurent; Boirie‌, Yves; Houlier, Marie-Louise; Morin, Liliane; Verdier, E.; Ritz, Patrick; Antoine, Jean‐Michel; Prugnaud, J.; Beaufrère, B.; Mirand, Philippe Patureau

doi:10.1093/ajcn/69.6.1202

Cited by 252 publications

(156 citation statements)

References 29 publications

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“…This phenomenon may partly explain reports [23,50 • ,51] that older adults require a higher protein intake or a protein 'pulse feeding' pattern, i.e. daily protein intake concentrated on one of the daily meals [52,53], to improve their nitrogen and amino acid balance.…”

Section: Amino Acids and Regulation Of Muscle Metabolism In Healthy Amentioning

confidence: 97%

Amino acid metabolism and regulatory effects in aging

Timmerman

Volpi²

2008

Current Opinion in Clinical Nutrition and Metabolic Care

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Purpose of review-To examine recent discoveries related to the amino acid metabolism and regulatory effects in aging, focusing on the development and treatment of age-related muscle loss (sarcopenia).Recent findings-While basal amino acid metabolism may be unaffected by age, elderly subjects appear to have a decreased ability to respond to anabolic stimuli such as insulin and, to a lesser extent, amino acids. Specifically, compared to young subjects, the stimulation of muscle protein synthesis is attenuated in elderly subjects following the administration of mixed meals due to insulin resistance. In addition, the anabolic effect of amino acids appears blunted at low doses. Recent studies, however, have highlighted that these age-related alterations in amino acid metabolism may be overcome by provision of excess leucine, changes in the daily protein intake pattern or exercise, which improve activation of translation initiation and muscle protein synthesis.Summary-Muscle loss with aging is associated with significant changes in amino acid metabolism, which can be acutely reversed using nutritional manipulations and exercise. Longterm, large clinical trials are, however, needed to determine the clinical significance of these findings in the elderly population, and to establish if nutritional and exercise interventions can help prevent and treat sarcopenia.

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Section: Amino Acids and Regulation Of Muscle Metabolism In Healthy Amentioning

confidence: 97%

Amino acid metabolism and regulatory effects in aging

Timmerman

Volpi²

2008

Current Opinion in Clinical Nutrition and Metabolic Care

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“…Our discussion focuses on the effects of the intervention as exploring pre-sarcopenia was the initial aim of this investigation. Many researchers performed investigations that focused on exercise and nutritional intake to control the decline of muscle mass and strength in patients with sarcopenia (Campbell, Crim, Dallal, Young, & Evans, 1994;Arnal et al, 1999;Kim et al, 2012;Rondanelli et al, 2016), but the results of these studies have not always been consistent (Kerstetter et al, 2005;Dillon et al, 2009;Paddon-Jones & Rasmussen, 2009). Our study demonstrates that the arm and leg muscle mass, hand grip strength, and walking speed did not increase with combined exercise and amino acid ingestion in both groups; however, the SMI improved only in the exercise and amino acid supplement group.…”

Section: Discussionmentioning

confidence: 99%

Combining Amino Acid and Vitamin D Supplementation with Exercise Training Increases Skeletal Muscle Mass and Prevent Bone Mineral Density Loss in Participants with Low Muscle Mass

Thu

Kurose

Fukushima

et al. 2017

GJHS

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This study evaluated the impact of exercise training with amino acid and vitamin D supplementation on muscle and bone mass in participants with low muscle volume. Twenty-nine Japanese participants (56-84 years old) were enrolled and assigned into the supplement (n=15) and non-supplement (n=14) groups. All participants underwent a 6-month exercise program. Supplements and nutrition support were provided to the participants in the supplement group for 12 weeks. Body composition and whole bone mineral density (BMD) were measured using dual energy x-ray absorptiometry. The outcomes, including body composition, whole BMD, and skeletal muscle mass index (SMI), were evaluated twice: pre-and post-intervention. The SMI was 6.51(6.28; 7.14) and 5.58 (5.24; 6.05) (kg/m 2 ) in men and women, respectively. The average SMI change was 0.13% (-0.05%; 0.31%) and 2.33% (-0.88%; 5.48%); [mean (lower; upper quartile)]. The average BMD loss in the non-supplement group was -2.78%, and the BMD increased in the supplement group by 4.34%; there was an absolute difference between the two groups (p<0.05). After the intervention, serum myostatin was changed (p=0.001, non-supplement>supplement), serum vitamin D was increased (p=0.03; supplement>non-supplement), and BMD was maintained (p=0.03, supplement>non-supplement). There was a significant difference in the serum myostatin level at baseline and at 6-month in the non-supplement group, with a mean difference of 0.48 ng/ml (p=0.01). There was no significant improvement in the total lean mass, and handgrip strength. Resistance exercise combined with an amino acid supplement affects muscle and bone mass in the short-term intervention.

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“…In older individuals, however, it appears that proteins that are rapidly digested and absorbed induce a better anabolic response as compared with the 'slower' proteins (Dangin et al 2002). Arnal et al (1999Arnal et al ( , 2000 found that the protein-feeding pattern is also important for optimal N retention. Specifically, they found that in older women protein pulse feeding induces a better N retention as compared with continuous feeding (Arnal et al 1999), whereas this is not true in younger individuals (Arnal et al 2000).…”

Section: Splanchnic Tissues and Muscle Protein Metabolism In The Elderlymentioning

confidence: 99%

Nutrition and sarcopenia of ageing

Fujita

Volpi

2004

Nutr. Res. Rev.

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Sarcopenia, the loss of muscle mass and function with ageing, is a multifactorial condition that slowly develops over decades and becomes a significant contributor to disability in the older population. Malnutrition and alterations in the muscle anabolic response to nutritional stimuli have been identified as potentially preventable factors that may significantly contribute to sarcopenia. In the present article we review the most recent findings regarding the role of nutritional factors in the development, prevention and treatment of sarcopenia. Specifically, we focus on the nutritional needs of the elderly; the age-related changes in the response of muscle protein metabolism to feeding and to the endogenous hormones released during feeding; and the role played by the splanchnic tissues in the response of muscle proteins to feeding. Finally, we review the issues relative to the potential use of nutritional therapies, including supplementation, for the prevention and treatment of sarcopenia. Ageing: Sarcopenia: Protein metabolism

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Protein pulse feeding improves protein retention in elderly women

Abstract: A protein pulse-feeding pattern was more efficient than was a protein spread-feeding pattern in improving, after 14 d, whole-body protein retention in elderly women.

Cited by 252 publications

References 29 publications

Amino acid metabolism and regulatory effects in aging

Amino acid metabolism and regulatory effects in aging

Combining Amino Acid and Vitamin D Supplementation with Exercise Training Increases Skeletal Muscle Mass and Prevent Bone Mineral Density Loss in Participants with Low Muscle Mass

Nutrition and sarcopenia of ageing

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