Abstract:Malaria is one of the most deadly diseases infecting humans. Advances in elimination and vector control have reduced the global malaria burden in the past decade; however, the emerging threat of drug resistance and suboptimal vaccine efficacies threaten global eradication efforts. Unlocking novel drug and vaccine targets while simultaneously mitigating spread of resistant strains seems to be the need of the hour. Protein-protein interactions (PPIs), an integral part of hostpathogen cross-talk and parasite surv… Show more
“…To handle these, new targets for drug and vaccine development are sought after, so with increased understanding of the host-pathogen malaria interactome comes the possibility for new targets and treatments, which are currently under investigation [10].…”
There are up to 650,000 ‘undruggable’ protein-protein interactions (PPIs) in the human interactome that can be potentially considered as novel therapeutic targets. How does the ‘undruggable’ become ‘druggable’?
“…To handle these, new targets for drug and vaccine development are sought after, so with increased understanding of the host-pathogen malaria interactome comes the possibility for new targets and treatments, which are currently under investigation [10].…”
There are up to 650,000 ‘undruggable’ protein-protein interactions (PPIs) in the human interactome that can be potentially considered as novel therapeutic targets. How does the ‘undruggable’ become ‘druggable’?
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