Abstract:Cytochrome P450 (P450, CYP) and uridine 5′ -diphospho-glucuronosyltransferase (UGT) are major drugmetabolizing enzymes known to catalyze substrate oxidation and glucuronidation, respectively. Both enzymes are located within the endoplasmic reticulum (ER) membrane; however, their membrane topologies diŠer, with P450 facing cytosol and a major part of UGTs located on the luminal side. Because of the large diŠerences in the reactions that they catalyze and their membrane topologies, it had been believed that P450… Show more
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