Protein-Protein Interaction of Retinoic Acid Receptor α and Thyroid Transcription Factor-1 in Respiratory Epithelial Cells

Abstract

Surfactant protein B (SP-B

A novel nonsense mutation in the TITF-1 gene in a Japanese family with benign hereditary chorea

“…Intrafamilial phenotypic variation in this disorder may be explained by differences in modifier genes that produce a different genetic background in the same family. Indeed, the activity of TITF-1 is highly dependent on its interactions with other transcription factors and coactivators, including GATA-6, NF-1, RAR, CBP/p300, SRC-1, and TAZ [29][30][31][32][33][34]. In addition, deficient transcriptional activity of mutant TITF-1 (p.P202L) was completely rescued by cotransfection of wild-type PAX8 in HEK293 cells [13].…”

Nuclear Factor of Activated T Cells Regulates Transcription of the Surfactant Protein D Gene (Sftpd) via Direct Interaction with Thyroid Transcription Factor-1 in Lung Epithelial Cells

“…For example, TTF-1 interacts with GATA6 to activate SP-C and Wnt7b transcription (47,67). Transcriptional co-activator TAZ and NFI interact with TTF-1 and synergistically activate the SP-C gene (65,68), whereas surfactant protein A and SP-B transcription is regulated by interaction of TTF-1 with CREB-binding protein and SRC-1 (66,69). TTF-1 also interacts with RAR/RXR and BR22 (66,70) to activate SP-B transcription.…”

“…TTF-1 synergistically activates transcription of lung surfactant genes and several genes involved in lung development by direct proteinprotein interaction or functional cooperation with a number of transcription factors (47,65,66). For example, TTF-1 interacts with GATA6 to activate SP-C and Wnt7b transcription (47,67).…”

GATA-6 and Thyroid Transcription Factor-1 Directly Interact and Regulate Surfactant Protein-C Gene Expression

“…There is increasing evidence that TTF-1 functions cooperatively with a number of other transcription factors, forming complexes on regulatory regions of target genes. TTF-1 interacts with retinoic acid receptors (RARs) and associated cofactors (13), nuclear factor-1, 2 AP1 family members (14), and BR22 (15). Depending on the sites and context of elements within target genes, TTF-1 can act directly or cooperatively with these various factors to regulate gene expression.…”