Protein–protein interaction network-based integration of GWAS and functional data for blood pressure regulation analysis
Evridiki-Pandora G. Tsare,
Maria I. Klapa,
Nicholas K. Moschonas
Abstract:Background
It is valuable to analyze the genome-wide association studies (GWAS) data for a complex disease phenotype in the context of the protein–protein interaction (PPI) network, as the related pathophysiology results from the function of interacting polyprotein pathways. The analysis may include the design and curation of a phenotype-specific GWAS meta-database incorporating genotypic and eQTL data linking to PPI and other biological datasets, and the development of systematic workflows for… Show more
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