Protein Profiling of Women with Spontaneous Preterm Birth

L, Immaculate Mbongo; A, Yamunah Devi; Zain, Sharifuddin M.; Sz, Omar; Mohamed, Zahurin

doi:10.1159/000430857

Cited by 8 publications

(5 citation statements)

References 23 publications

(36 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Smoking reduces the risk of gestational hypertension and mild preeclampsia (67,68), but increases the risk of fetal growth restriction and preterm delivery (69). The smoking-associated increase in serum IL-17 shown here may relate to the potential role for IL-17 in pregnancies complicated by placental insufficiency (70) or preterm labor (71), and increased IL-17 has been shown in non-pregnant smokers (72). Smoking status was recorded only at inclusion in this study, thus the effect of continued smoking on the maternal immune status in pregnancy should be investigated further.…”

Section: Discussionmentioning

confidence: 77%

Cytokine Patterns in Maternal Serum From First Trimester to Term and Beyond

et al. 2021

View full text Add to dashboard Cite

Pregnancy implies delicate immunological balance between two individuals, with constant changes and adaptions in response to maternal capacity and fetal demands. We performed cytokine profiling of 1149 longitudinal serum samples from 707 pregnant women to map immunological changes from first trimester to term and beyond. The serum levels of 22 cytokines and C-reactive protein (CRP) followed diverse but characteristic trajectories throughout pregnancy, consistent with staged immunological adaptions. Eotaxin showed a particularly robust decrease throughout pregnancy. A strong surge in cytokine levels developed when pregnancies progressed beyond term and the increase was amplified as labor approached. Maternal obesity, smoking and pregnancies with large fetuses showed sustained increase in distinct cytokines throughout pregnancy. Multiparous women had increased cytokine levels in the first trimester compared to nulliparous women with higher cytokine levels in the third trimester. Fetal sex affected first trimester cytokine levels with increased levels in pregnancies with a female fetus. These findings unravel important immunological dynamics of pregnancy, demonstrate how both maternal and fetal factors influence maternal systemic cytokines, and serve as a comprehensive reference for cytokine profiles in normal pregnancies.

show abstract

Section: Discussionmentioning

confidence: 77%

Cytokine Patterns in Maternal Serum From First Trimester to Term and Beyond

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Single nucleotide polymorphisms of TGFBR3 have been found to be associated with gestational duration. 54 However, cytokines were below the detection threshold in our mass spectrometry analysis precluding comparisons. 54 However, cytokines were below the detection threshold in our mass spectrometry analysis precluding comparisons.…”

Section: Commentmentioning

confidence: 88%

“…53 Various cytokines have also been associated with spontaneous preterm birth. 54 However, cytokines were below the detection threshold in our mass spectrometry analysis precluding comparisons.…”

Section: Commentmentioning

confidence: 88%

Amniotic fluid proteomic signatures of cervical insufficiency and their association with length of latency

Govia

Birse

Sepehri

et al. 2018

American J Rep Immunol

View full text Add to dashboard Cite

In this pilot study, significant differences in the amniotic fluid proteomic profiles in cases of cervical insufficiency compared to genetic amniocentesis were observed. Proteomic signatures were predictive of achieving latency > 1 week after diagnosis of cervical insufficiency. These preliminary findings suggest that proteomic analysis may be of value in predicting outcome following cervical insufficiency and warrants further validation in larger studies.

show abstract

“…Prior studies have identified that elevated inflammatory factors in maternal circulation, amniotic fluid, and cervicovaginal fluid during the second trimester, including among individuals with no sign of clinical infection, are consistently associated with earlier gestational age at delivery and increased risk of preterm birth. [24][25][26][27][28][29] In particular, higher levels of pro-inflammatory IL-6, 24,26,29 IL-8, 26 TNF-α, 27 IFN-ɣ, 24 the acute phase C-reactive protein (CRP), 29,30 and anti-inflammatory IL-13 28 and IL-10 25,28 measured between 12 and 27 weeks gestation have been associated with greater odds of preterm delivery and other adverse pregnancy outcomes. These associations could represent a causal relationship between chronic inflammation and poorer quality of the gestational environment, because excessive immunologic activity at the maternal-fetal interface can interfere with adequate vascularization of the placenta.…”

Section: Introductionmentioning

confidence: 99%

Using principal component analysis to examine associations of early pregnancy inflammatory biomarker profiles and adverse birth outcomes

Keenan-Devlin

Caplan

Freedman

et al. 2021

American J Rep Immunol

View full text Add to dashboard Cite

Objective: Inflammation as a risk factor for preterm birth is well-established. The primary objective of this analysis was to examine whether individual cytokines versus a composite indicator of mid-pregnancy inflammation are significantly associated with risk for adverse birth outcomes. Study design:A multi-site prospective study was conducted in a socio-demographically diverse cohort of 610 pregnant participants. At a study visit between 12 and 20 6/7 weeks' gestation, low-grade inflammation was measured via log-transformed serum concentrations of the biomarkers IFN-γ, IL-10, IL-13, IL-6, IL-8, TNF-α, and CRP. Principal component analysis (PCA) was used to identify underlying dimensions of inflammatory activity from the seven biomarkers measured. Gestational age and birth weight at delivery were obtained from medical chart review. The associations between inflammatory profiles and birth outcomes were assessed via linear and logistic regression models. Results were compared with those from individual inflammatory biomarkers, and model fit was assessed using Akaike's Information Criterion (AIC).Results: Principal component analysis analysis yielded a two-factor solution, with the first factor (IF1) composed of IL-8, IL-10, IL-13, IFN-ɣ, and TNF-α, and the second

show abstract

Protein Profiling of Women with Spontaneous Preterm Birth

Cited by 8 publications

References 23 publications

Cytokine Patterns in Maternal Serum From First Trimester to Term and Beyond

Cytokine Patterns in Maternal Serum From First Trimester to Term and Beyond

Amniotic fluid proteomic signatures of cervical insufficiency and their association with length of latency

Using principal component analysis to examine associations of early pregnancy inflammatory biomarker profiles and adverse birth outcomes

Contact Info

Product

Resources

About