2023
DOI: 10.1002/mco2.261
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Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

Abstract: Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent bonds on the backbones or amino acid side chains of proteins and expand the diversity of proteins, which provides the basis for the emergence of organismal complexity. To date, more than 650 types of protein modifications, such as the most well‐known phosphorylation, ubiquitination, glycosylation, methylation, SUMOylation, short‐chain and long‐chain acylation modifications, redox modifications, and irreversible modif… Show more

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Cited by 40 publications
(25 citation statements)
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“…1 Due to their fundamental functions in cell signaling, 2,3 to target the dynamics (including the installation and removal) of protein PTMs becomes a considerable therapeutic strategy for human disease treatment. 4 In general, the dynamics of protein PTMs are regulated by “writer” and “eraser” enzymes. 5 In the past years, we focused on non-canonical protein PTMs that do not require writers (such as non-enzymatic glycation), 69 or in which the installation and removal are regulated by a single enzyme (such as monoaminylation).…”
Section: Introductionmentioning
confidence: 99%
“…1 Due to their fundamental functions in cell signaling, 2,3 to target the dynamics (including the installation and removal) of protein PTMs becomes a considerable therapeutic strategy for human disease treatment. 4 In general, the dynamics of protein PTMs are regulated by “writer” and “eraser” enzymes. 5 In the past years, we focused on non-canonical protein PTMs that do not require writers (such as non-enzymatic glycation), 69 or in which the installation and removal are regulated by a single enzyme (such as monoaminylation).…”
Section: Introductionmentioning
confidence: 99%
“…Alternatively, phospho-signals, serving as the first wave of response to intracellular and extracellular changes, extensively exist during the EMT process [65,66]. For example, phosphorylation of SNAIL [67], GSK3β [68], and EGFR [69] contributes to the regulation of EMT.…”
Section: Discussionmentioning
confidence: 99%
“…Mg deficiency is well known to cause inflammation by disturbing the coordination of the innate immune system and the adaptive immune response[14], leading to rapid loss of cell adhesion molecules[46−48]. Alternatively, phospho-signals, serving as the first wave of response to intracellular and extracellular changes, extensively exist during the EMT process[65, 66]. For example, phosphorylation of SNAIL[67], GSK3β[68], and EGFR[69] contributes to the regulation of EMT.…”
Section: Discussionmentioning
confidence: 99%
“…PTMs modulate the function of proteins by regulating their localization, interactions, stability, and turnover, thereby influencing protein homeostasis (proteostasis) (Zhong et al, 2023). Loss of proteostasis is a hallmark of aging (Santra et al, 2019;C.…”
Section: Introductionmentioning
confidence: 99%