“…12 This suggests that such molecular glues modulating protein assembly are likely more abundant and that it should be possible to identify them in small molecule screens. 13…”
Small molecules have been shown to not only mediate and enhance polymerization, in a manner analogous to a surface residue mutation or post-translational modification, but also bind and stabilize the repeating unit to inhibit self-assembly.
“…12 This suggests that such molecular glues modulating protein assembly are likely more abundant and that it should be possible to identify them in small molecule screens. 13…”
Small molecules have been shown to not only mediate and enhance polymerization, in a manner analogous to a surface residue mutation or post-translational modification, but also bind and stabilize the repeating unit to inhibit self-assembly.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.