Protein Painting Mass Spectrometry in the Discovery of Interaction Sites within the Acetylcholine Binding Protein
Alexandru Graur,
Amanda Haymond,
Kyung Hyeon Lee
et al.
Abstract:Nicotinic acetylcholine receptors (nAChRs) are a family of ligand-gated ion channel receptors that contribute to cognition, memory, and motor control in many organisms. The pharmacological targeting of these receptors, using small molecules or peptides, presents an important strategy for the development of drugs that can treat important human diseases, including neurodegenerative disorders. The Aplysia californica acetylcholine binding protein (Ac-AChBP) is a structural surrogate of the nAChR with high homolog… Show more
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