Protein oxidation markers in women with and without gestational diabetes mellitus: A possible relation with paraoxonase activity

Gelışgen, Remise; Genc, Habibe; Kayalı, Refik; Öncül, Mahmut; Benian, Ali; Güralp, Onur; Uludağ, Seyfettin; Çakatay, Ufuk; Albayrak, Mustafa; Uzun, Hafize

doi:10.1016/j.diabres.2011.08.001

Cited by 49 publications

(37 citation statements)

References 36 publications

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“…Some of these effects have been shown to be ameliorated by the concomitant consumption of antioxidants such as vitamin C (19) . In the current study, effects on both lipid peroxidation as well as protein oxidation (using PON-1 activity as a surrogate marker (21) ) were investigated. It was seen that women who started their pregnancy with a high Hb 1 actually had a higher level of oxidative stress as evidenced by higher levels of LPO and lower PON-1 activity in T1 (Table 2).…”

Section: Discussionmentioning

confidence: 99%

“…It therefore has a protective role against cellular damage from oxidative stress (22) and low serum PON-1 activity is associated with increased risk of atherosclerosis (7,23) as well as adverse birth outcomes (10,21) . The activity of PON-1 in T1 was significantly lower among women who delivered LBW babies (Table 3).…”

Section: Discussionmentioning

confidence: 99%

“…Studies have shown that increased protein oxidation markers and lowered PON-1 activity in early pregnancy could predict clinical complications like pre-eclampsia and gestational diabetes mellitus (10,21) . In combination with the current finding of higher oxidative stress and lower PON-1 activity in T1 also being associated with high Hb 1 as well as LBW, the potential of PON-1 being used as an early marker of gestational morbidities is worth investigating.…”

Section: Pon-mentioning

confidence: 99%

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Oxidative stress during early pregnancy and birth outcomes

Shastri

Pammal

Mani

et al. 2016

Public Health Nutr.

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Objective: Routine high-dose Fe supplementation in non-anaemic pregnant women may induce oxidative stress and eventually affect birth outcomes. The aim of the present study was to measure oxidative stress markers in pregnant women with low/normal and high Hb values in trimester 1 (Hb 1 ) and to relate these to birth weight. Design: A cross-sectional study where selected oxidative stress markers were analysed in both maternal (trimester 1; T1) and cord blood samples and correlated with birth weight. Setting: A tertiary hospital in urban South India. Subjects: One hundred women were chosen based on their Hb 1 values (forty women with low/normal Hb 1 (<110 g/l) and sixty women with high Hb 1 (≥120 g/l)). Results: In T1, women with high Hb 1 values were found to have lower paraoxonase-1 (PON-1) activity (424·7 (SD 163·7) v. 532·9 (SD 144·7) pmol p-nitrophenol formed/min per ml plasma, P = 0·002) and higher lipid peroxides compared with women with low/normal Hb 1 . Routine supplementation of Fe to these women resulted in persistent lower PON-1 activity in cord blood (P = 0·02) and directionally lower (P = 0·142) birth weights. Furthermore, women with high Hb 1 who delivered low-birth-weight babies were observed to have lowest PON-1 activity in T1. No changes were observed in other markers (myeloperoxidase activity and total antioxidant levels). Conclusions: Routine Fe supplementation in pregnant women with high Hb 1 associated with increased oxidative stress, as reflected by low PON-1 activity in T1, could potentially lead to deleterious effects on birth weight.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Pon-mentioning

confidence: 99%

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Oxidative stress during early pregnancy and birth outcomes

Shastri

Pammal

Mani

et al. 2016

Public Health Nutr.

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“…Glycemic levels in GDM were correlated with concentrations of lipid peroxides and increased protein oxidation [14]. Increased biomarkers of oxygen radical damage have been identified in GDM, such as myeloperoxidase and malonaldehyde levels [15,16]. These preliminary results demonstrated that the increase in the levels of BChE, γ-GT, Cys-C, and pre-albumin may be indicative of oxidative stress in GDM.…”

Section: Discussionmentioning

confidence: 54%