Protein oxidation in a group of subjects with metabolic syndrome

Caimi, Gregorio; Hopps, Eugenia; Noto, Davide; Canino, Baldassare; Montana, M.; Lucido, Daniela; Presti, Rosalia Lo; Averna, Maurizio

doi:10.1016/j.dsx.2013.02.013

Cited by 13 publications

(14 citation statements)

References 42 publications

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“…Our findings are consistent with other investigations regarding protein oxidation in patients with full-blown metabolic syndrome [11]. Caimi et al [31] observed higher concentration of carbonyl groups in these patients and Korkmaz et al [22] found increased AOPP levels and pro-oxidant/antioxidant balance (PAB) values. Higher IMA levels in MetS patients were observed by Valle-Gottlieb et al [5] in association with cardiometabolic risk factors in MetS.…”

Section: Discussionsupporting

confidence: 93%

Oxidatively modified forms of albumin in patients with risk factors of metabolic syndrome

Żurawska-Płaksej

Grzebyk

Marciniak

et al. 2014

J Endocrinol Invest

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BackgroundMetabolic syndrome (MetS) is a complex metabolic disease connected especially with lipid and carbohydrate disturbances. It is postulated that oxidative stress (OS) is linked to metabolic syndrome, constituting a novel component of its pathogenesis.AimWe aimed to examine the plasma level of oxidatively modified proteins––advanced oxidation protein products (AOPP) and ischemia modified albumin (IMA)––as well as thiol (SH) groups and evaluate their connection with metabolic agents in relation to MetS prevalence.Subjects and methodsThe levels of AOPP, IMA and SH groups were measured spectrophotometrically in 106 patients with MetS risk factors and in 32 control subjects.ResultsThe levels of examined parameters differed significantly between patients with MetS risk factors and the control group. AOPP significantly correlated with glucose (r = 0.30, p = 0.008), HDL-Ch (r = −0.34, p = 0.005), TG (r = 0.48, p < 0.001) and fibrinogen (r = 0.37, p < 0.001). The levels of AOPP and IMA increased progressively with the number of MetS risk factors, being the most significant for AOPP. The highest values of AOPP were associated with the presence of at least three risk factors. Only AOPP were an independent determinant for MetS occurrence in the studied population (OR = 2.72, p = 0.04). Mutual dependence between metabolic, oxidative stress and inflammatory parameters was revealed.ConclusionsOxidative modifications of proteins are increased in MetS and accumulation of MetS risk factors enhances manifestation of OS. AOPP is the most appropriate parameter for determination of OS, with potential diagnostic value in MetS patients.

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Section: Discussionsupporting

confidence: 93%

Oxidatively modified forms of albumin in patients with risk factors of metabolic syndrome

Żurawska-Płaksej

Grzebyk

Marciniak

et al. 2014

J Endocrinol Invest

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“…Regarding stress markers, our results demonstrate that the post-treatment PG showed a nearly nearly 50% increase in carbonylated proteins. Similar results have been obtained by other authors, independently of the presence or absence of T2DM in patients with MetS [45]. This type of damage can lead to protein structural modifications, dysfunctionality, and proteolysis susceptibility [46].…”

Section: Discussionsupporting

confidence: 89%

Effect of Sechium edule var. nigrum spinosum (Chayote) on Telomerase Levels and Antioxidant Capacity in Older Adults with Metabolic Syndrome

et al. 2020

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Patients with metabolic syndrome (MetS) have a redox imbalance, due to a decay in antioxidant capacity. Oxidative stress (OxS) is considered an important modulator of telomere shortening and telomerase activity. One of the fruits that has been associated with an antioxidant effect is Sechium edule and although its properties are well established, there is only one exploratory study evaluating its effectiveness in patients with MetS. The present investigation is a much more robust and controlled study, including a placebo group. Hence, we determined the effect of consumption of the dried fruit powder (500 mg, three times per day) for three months. We measured effects on telomerase levels, antioxidant capacity, and markers for OxS. The study was performed in a sample of 75 older adults: placebo group (n = 30) and experimental group (n = 45) with the diagnosis of MetS according to the National Adult Treatment Panel of the National Cholesterol Program III (NCEP/ATP III) criteria. All markers were measured before and after three months of treatment. There was a statistically significant decrease in lipoperoxides and protein carbonylation with an increased superoxide dismutase (SOD), as well as sustained levels of telomerase in patients who consumed Sechium edule. Our findings suggest that consumption of this fruit has a hypoglycemic, hypotensive, and antioxidant effect, without altering telomerase levels, which could suggest better protection against telomere shortening.

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“…Moreover, a cross-sectional study conducted on the limited number of Japanese MetS patients and healthy subjects indicated an increase of systemic OxS, as determined by urinary 8-epiprostaglandin F2α (8-epi-PGF2α) in single urine samples, being correlated with visceral AT (VAT) accumulation [55]. MetS patients, including those with T2DM, also exhibited elevation of plasma thiobarbituric acid reactive substances (TBARS), protein carbonylation products, and NOx, where the latter indicated the phenomenon of nitrosative stress (NS) [56][57][58]. Additionally, study on MetS and healthy subjects reported raised values for advanced oxidation protein products (AOPP) and pro-oxidant-antioxidant balance (PAB), in plasma and serum, respectively [59].…”

Section: The Interplay Between Oxidative Stress and Metabolic Syndromementioning

confidence: 99%

The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress

Włodarski

Strycharz

Wróblewski

et al. 2020

IJMS

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Oxidative stress (OxS) is the cause and the consequence of metabolic syndrome (MetS), the incidence and economic burden of which is increasing each year. OxS triggers the dysregulation of signaling pathways associated with metabolism and epigenetics, including microRNAs, which are biomarkers of metabolic disorders. In this review, we aimed to summarize the current knowledge regarding the interplay between microRNAs and OxS in MetS and its components. We searched PubMed and Google Scholar to summarize the most relevant studies. Collected data suggested that different sources of OxS (e.g., hyperglycemia, insulin resistance (IR), hyperlipidemia, obesity, proinflammatory cytokines) change the expression of numerous microRNAs in organs involved in the regulation of glucose and lipid metabolism and endothelium. Dysregulated microRNAs either directly or indirectly affect the expression and/or activity of molecules of antioxidative signaling pathways (SIRT1, FOXOs, Keap1/Nrf2) along with effector enzymes (e.g., GPx-1, SOD1/2, HO-1), ROS producers (e.g., NOX4/5), as well as genes of numerous signaling pathways connected with inflammation, insulin sensitivity, and lipid metabolism, thus promoting the progression of metabolic imbalance. MicroRNAs appear to be important epigenetic modifiers in managing the delicate redox balance, mediating either pro- or antioxidant biological impacts. Summarizing, microRNAs may be promising therapeutic targets in ameliorating the repercussions of OxS in MetS.

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Protein oxidation in a group of subjects with metabolic syndrome

Cited by 13 publications

References 42 publications

Oxidatively modified forms of albumin in patients with risk factors of metabolic syndrome

Oxidatively modified forms of albumin in patients with risk factors of metabolic syndrome

Effect of Sechium edule var. nigrum spinosum (Chayote) on Telomerase Levels and Antioxidant Capacity in Older Adults with Metabolic Syndrome

The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress

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