1990
DOI: 10.1007/978-1-4684-5730-8_77
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Protein Oxidation and Proteolytic Degradation General Aspects and Relationship to Cataract Formation

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Cited by 27 publications
(10 citation statements)
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“…Limited information is available on composition and activity of the proteasome or molecular chaperones in aging. Initial studies have indicated defects in proteasome activity in disease and aging [19,[116][117][118] . [For references 119-129 see table 2.]…”
Section: Discussionmentioning
confidence: 99%
“…Limited information is available on composition and activity of the proteasome or molecular chaperones in aging. Initial studies have indicated defects in proteasome activity in disease and aging [19,[116][117][118] . [For references 119-129 see table 2.]…”
Section: Discussionmentioning
confidence: 99%
“…These modifications, individually or collectively, lead to increased crystallin aggregation and precipitation. Lens proteases are involved in morphogenesis and in maintaining the clarity of the lens by degrading oxidized and modified proteins and peptides (3)(4)(5)(6). Several proteolytic enzymes have been shown to play a role in lens aging and cataract formation (7)(8)(9)(10)(11)(12)(13).…”
mentioning
confidence: 99%
“…Our interest in studying the antioxidant potency of diverse hormones and plant-derived compounds used in postmenopausal women is based on the fact that oxidation of LDLs is thought to play an important role in the pathogenesis of atherosclerosis 20 , cancer development 21 , in the autoimmune destruction of b cells leading to diabetes 22 , as mediators of inflammatory damage in asthma 23 and in joints in rheumatoid arthritis 24 and in the process leading to cataracts 25 . In this respect, it has been demonstrated that phytoestrogens are antioxidants because of their free radical scavenging properties and because they are chelators of metal ions 13,26 .…”
Section: Discussionmentioning
confidence: 99%