Protein Metabolism of The Nervous System

Lajtha, Ábel

doi:10.1016/s0074-7742(08)60767-9

Cited by 118 publications

(17 citation statements)

References 415 publications

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“…Moreover, once a structural change in a neural circuit has occurred, there is no necessity for long life times for the proteins used. This is consistent with the relatively short half life of 14 days reported by Lajtha (1964) for over 98% of brain proteins. The proposed mechanism takes into account the dynamic nature of brain protein and RNA metabolism.…”

Section: En Environment; E-t Electrical-time; E-s Electrical-spacesupporting

confidence: 90%

Letters to the Editor

1972

International Journal of Neuroscience

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Section: En Environment; E-t Electrical-time; E-s Electrical-spacesupporting

confidence: 90%

Letters to the Editor

1972

International Journal of Neuroscience

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“…There are many differences in rate of protein turnover [4] in different cell types and in smaller regions, but these are not reflected in the relatively large regions studied. The measurement of radioactivity in protein of such regions is a resultant of the incorporation into the numerous protein fractions existing in the brain.…”

Section: Discussionmentioning

confidence: 93%

“…In vitro investigations have revealed that protein turnover is more rapid in immature brain tissue than in adult animals [3,4,6]. Studies in which longitudinal data have been obtained have revealed a progressive diminution of rate in incorporation of labeled amino acids into protein over a period of weeks or months.…”

Section: Discussionmentioning

confidence: 99%

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Postnatal Changes in Protein Metabolism of Brain: I. Studies in Newborn Miniature Pigs at Varying Conceptual Ages

1969

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ExtractT h e incorporation of L-phenylalanine-14C into protein of several brain areas and into liver of the miniature pig has been studied in viuo. A sequential decrease (approximately 50 %) in incorporation of labeled phenylalanine occurred during the first day of life in all brain regions ( fig. 1). There was no important difference in degree of incorporatn ioin the three brain regions examined. Labeling of liver protein was roughly threefold higher than in brain protein. A considerably smaller postnatal decrease of labeling of liver protein occurred in proportion to the total initial count.Premature delivery by hysterectomy a t two different conceptual ages resulted in a similar reduction of labeling of brain protein fractions, suggesting that birth rather than the conceptual age of the animal was the relevant factor ( figs. 2 and 3).Radioactivity in the trichloracetic acid-soluble fraction (free amino acids) of all brain areas increased during the first day of life, suggesting that the decreased incorporation of labeled amino acid was not a function of failure of the tracer to enter into brain substance (fig. 4).Expression of the radioactivity of protein in the brain regions as a function of radioactivity of liver protein established that while there is some postnatal decrease of incorporation into liver protein, there is a relatively greater decrease of incorporation into various brain regions (table I ) . Speculation

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“…Available studies on polyribosomal profile during early development stem from comparisons of changes in the turnover and nature of protein during development between the early neonate and the adult animal [51][52][53]. Ribosomes from neonatal rat brain seem to be significantly more active in amino acid incorporation in vitro than ribosomes from adult rat brain [54,55] and have a larger number of larger than 80 S polysomes [56,57].…”

Section: Rna Metabolismmentioning

confidence: 99%