Protein Metabolism and Erythropoiesis. II. Erythropoietin Formation and Erythroid Responsiveness in Protein-deprived Rats

Reißmann, Kurt R.; Dietrich, Mary Ruth; Kennedy, Myrle Jean

doi:10.1182/blood.v23.2.146.146

Cited by 52 publications

(5 citation statements)

References 6 publications

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“…Reissman (1964) reported anaemia in malnourished rats and suggested as a mechanism a slow-down in protein synthesis in erythroid cells and/or a reduction in erythropoietin synthesis. Aschkenasy (1957) observed, in protein malnutrition, the presence of anaemia and leucopenia, and erythroid marrow hyperplasia without a simultaneous elevation in erythropoietin concentration.…”

Section: Discussionmentioning

confidence: 99%

“…Studies (Fried & Gurney, 1965; Seifter et al 1971; Aschkenasy, 1975) have demonstrated that, in rats, a fall in erythropoietin occurred due to the reduced ingestion of protein, in opposition to the results obtained in our study. Serum concentrations of erythropoietin were found to be both increased (Macdougall et al 1982; el-Nawawy et al 2002) and decreased (Reissman, 1964; Catchatourian et al 1980) in protein malnutrition and protein-energy malnutrition, the reduction being attributed to a decrease in the speed of O use by the tissues.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, these same authors suggested that among the causes of anaemia in protein-energy malnutrition was an adaptation of the organism to the reduction in the demand for O and also to chronic infections, which are frequently present. Reissman (1964) reported anaemia in malnourished rats and suggested as a mechanism a slow-down in protein synthesis in erythroid cells and/or a reduction in erythropoietin synthesis. Aschkenasy (1957) observed, in protein malnutrition, the presence of anaemia and leucopenia, and erythroid marrow hyperplasia without a simultaneous elevation in erythropoietin concentration.…”

Section: Discussionmentioning

confidence: 99%

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Reduction of erythroid progenitors in protein–energy malnutrition

et al. 2007

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Protein -energy malnutrition is a syndrome in which anaemia together with multivitamin and mineral deficiency may be present. The pathophysiological mechanisms involved have not, however, yet been completely elucidated. The aim of the present study was to evaluate the pathophysiological processes that occur in this anaemia in animals that were submitted to protein-energy malnutrition, in particular with respect to Fe concentration and the proliferative activity of haemopoietic cells. For this, histological, histochemical, cell culture and immunophenotyping techniques were used. Two-month-old male Swiss mice were submitted to protein -energy malnutrition with a low-protein diet (20 g/kg) compared with control diet (400 g/kg). When the experimental group had attained a 20 % loss of their original body weight, the animals from both groups received, intravenously, 20 IU erythropoietin every other day for 14 d. Malnourished animals showed a decrease in red blood cells, Hb concentration and reticulocytopenia, as well as severe bone marrow and splenic atrophy. The results for serum Fe, total Fe-binding capacity, transferrin and erythropoietin in malnourished animals were no different from those of the control animals. Fe reserves in the spleen, liver and bone marrow were found to be greater in the malnourished animals. The mixed colony-forming unit assays revealed a smaller production of granulocyte -macrophage colony-forming units, erythroid burst-forming units, erythroid colony-forming units and CD45, CD117, CD119 and CD71 expression in the bone marrow and spleen cells of malnourished animals. These findings suggest that, in this protein-energy malnutrition model, anaemia is not caused by Fe deficiency or erythropoietin deficiency, but is a result of ineffective erythropoiesis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Reduction of erythroid progenitors in protein–energy malnutrition

et al. 2007

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“…[ 13 ] examined overall toxicological parameters with feed restriction for 2 weeks at 75, 50 or 25% of the control diet and found a myelosuppression in bone marrow in all the feed-restricted groups, indicating that the primary response to the feed restriction was hematopoietic suppression in rats. Other examinations focusing on hematopoiesis in feed-restricted rodents showed a decreased blood cell count and hypocellularity in bone marrow [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 15 , 17 , 19 ]. These rodent examinations suggested, as described by a number of review articles [ 15 , 21 , 22 ], the importance of hematopoietic evaluation in the malnourished condition.…”

Section: Introductionmentioning

confidence: 99%

Effects of four-week feed restriction on toxicological parameters in beagle dogs

et al. 2015

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This study was conducted to examine any changes caused by feed restriction in dogs to contribute to safety evaluation in toxicity studies. Two male 7-month-old beagle dogs/group were fed 300 (control), 150 (50% of control), or 70 g/animal of diet daily (23% of control) for 4 weeks. Effects of feed restriction, except for clinical signs, were noted depending on the feed dosage in almost all examinations. The principal outcomes were: decreased body weight and water consumption, ECG changes (decreased heart rate and prolonged QTc), and hematopoietic and lymphopoietic suppression (decreased reticulocyte ratio or white blood cell count in hematology, decreased nucleated cell count in bone marrow, decreased erythroid parameters in myelography, and hypocellularity of bone marrow and thymic atrophy in histopathology). In addition, some changes were noted in urinalysis (decreased urine volume and sodium and potassium excretion), blood chemistry (decreased ALP and inorganic phosphorus and increased creatinine), organ weights, and gastric histopathology. These results provide important reference data for distinguishing the primary effects of test compounds from secondary effects of decreased food consumption in toxicity studies in beagle dogs.

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“…From another perspective, individuals with elevated folate may be consuming foods high in folate, which are also high in phytates, ultimately reducing Fe absorption, a hypothesis that we could not test in this analysis. Further, those consuming high cereal diet, resulting in high folate, may also have lower intake of high-quality protein necessary for Hb production ( 58 ) .…”

Section: Discussionmentioning

confidence: 99%

Predictors of anemia in mothers and children in Uttar Pradesh, India

Larson,

Thomas,

Kurpad

et al. 2024

Public Health Nutr.

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Objective: Anemia affects more than half of Indian women and children, but the contribution of its causes remains unquantified. We examined interrelationships between hemoglobin and nutritional, environmental, infectious, and genetic determinants of anemia in non-pregnant mothers and children in Uttar Pradesh (UP). Design: We conducted a cross-sectional survey of households in 25 districts of UP between October and December 2016. We collected socio-demographic data, anthropometry, and venous blood in 1238 non-pregnant mothers and their children. We analyzed venous blood samples for malaria, hemoglobin, ferritin, retinol, folate, zinc, vitamin B12, C-reactive protein (CRP), α1-acid glycoprotein (AGP), and β-thalassemia. We used path analysis to examine pathways through which predictors of anemia were associated with hemoglobin concentration. Setting: Rural and urban households in 25 districts of UP. Participants: Mothers 18-49 years and children 6-59 months in UP. Results: A total of 36.4% of mothers and 56.0% of children were anemic, and 26.7% of women and 44.6% of children had iron deficiency anemia. Ferritin was the strongest predictor of hemoglobin [β (95% CI) = 1.03 (0.80, 1.27) g/dL in women and 0.90 (0.68, 1.12) g/dL in children]. In children only, red blood cell folate and AGP were negatively associated with hemoglobin and retinol was positively associated with hemoglobin. Conclusions: Over 70% of mothers and children with anemia had iron deficiency, needing urgent attention. However, several simultaneous predictors of hemoglobin exist, including nutrient deficiencies and inflammation. The potential of iron interventions to address anemia may be constrained unless coexisting determinants are jointly addressed.

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Protein Metabolism and Erythropoiesis. II. Erythropoietin Formation and Erythroid Responsiveness in Protein-deprived Rats

Cited by 52 publications

References 6 publications

Reduction of erythroid progenitors in protein–energy malnutrition

Reduction of erythroid progenitors in protein–energy malnutrition

Effects of four-week feed restriction on toxicological parameters in beagle dogs

Predictors of anemia in mothers and children in Uttar Pradesh, India

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