Protein-losing enteropathy in paracoccidioidomycosis identified by scintigraphy: report of three cases

Berni, Aline Dayara de Mendonça; Júnior, Erivaldo Elias; Filho, Adalberto Arão; Paniago, Anamaria Mello Miranda

doi:10.1590/s1413-86702010000500020

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…Lymphatic stasis causing infarct has been studied in protein losing enteropathy [20]. However, no significant sinus dilatations were seen nor any obstructions by adult worms or larvae were seen in the lymphatic channels or the blood vessels.…”

Section: Discussionmentioning

confidence: 99%

Ascaris lumbricoides causing infarction of the mesenteric lymph nodes and intestinal gangrene in a child: a case report

Bhutia

Dey²,

Vk³

et al. 2011

GMS German Medical Science; 9:Doc12; ISSN 1612-3174

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Section: Discussionmentioning

confidence: 99%

Ascaris lumbricoides causing infarction of the mesenteric lymph nodes and intestinal gangrene in a child: a case report

Bhutia

Dey²,

Vk³

et al. 2011

GMS German Medical Science; 9:Doc12; ISSN 1612-3174

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“…This condition is caused by dimorphic fungi of the genus Paracoccidioides, especially in rainy regions, with acidic and moist soil conditions 3 . Contact with the fungus is possible through transmission by inhalation, generally with predominantly pulmonary infection 4 . For the disease to develop, a transformation from the micellar form of the agent to its yeast-like pathogenic presentation takes place, which occurs at a temperature of 35 to 37°C 3 .…”

Section: Introductionmentioning

confidence: 99%

Case report: juvenile paracoccidioidomycosis with intestinal involvement

Da Silva,

Oliveira,

Alves

et al. 2024

Braz. J. Develop.

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Introduction: Contact of Paracoccidioides sp. with the human organism presents in a variety of clinical forms of the disease. Intestinal clinical manifestation is found in 10 to 30% of cases, commonly in juvenile form. This case report seeks to describe a patient with juvenile paracoccidioidomycosis with atypical intestinal involvement. Case report: A 14 years old woman with an updated vaccination schedule and no reports of chronic diseases, allergies or continued use of medications, presented a diarrheal condition that was characterized by pasty stools, where episodes became gradually more intense, associated with episodes of hematochezia, retroauricular lymphadenopathy on the right, as well as shivering and fever. A colonoscopy revealed multiple polypoid formations, ulcerations and friability throughout the colon. After biopsy results, the diagnosis of Paracoccidioidomycosis with intestinal involvement was established. Due to the wasting syndrome, anemia and persistent diarrhea, the patient was hospitalized for blood transfusion and intravenous treatment with conventional Amphotericin B. Discussion: Unlike what was presented by the patient in this case, involvement of the gastrointestinal tract is uncommon in paracoccidioidomycosis. This disease presents a range of clinical manifestations, which makes diagnosis difficult. Since this type of infection is not always considered, it may result in underdiagnosed cases, especially in women and young adults. The prognosis depends on the initial severity of the disease, the presence of comorbidities and the treatment used. Conclusion: Especially for the intestinal form, earlier treatment will better the results. The disease has a good chance of effective treatment using antifungal therapy.

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“…The fungus can spread from the lungs to other organs and tissues via lymphatic and hematogenic pathways . In the acute phase, the disease progresses more rapidly and clinical diagnosis is more difficult . Hepatosplenomegaly is a common occurrence in the acute phase with occurrence of granulomas, areas of necrosis and yeasts internalized in macrophages as observed in mice liver during the first weeks of infection .…”

Section: Introductionmentioning

confidence: 99%

Combination of Histopathology and FT‐Raman Spectroscopy for the Study of Experimental Paracoccidioidomycosis in the Spleen

Mansano¹,

Morais²,

Moratto³

et al. 2017

Photochem & Photobiology

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Paracoccidioides brasiliensis (Pb) can disseminate through the lymphatic and hematogenic pathways. As a result the spleen and other lymphoid organs are targets of paracoccidioidomycosis. There are few studies describing this disease in the spleen and more detailed descriptions are required. This study combines Histopathology and Fourier Transform Raman Spectroscopy (FT‐Raman) methods to study spleen infected by Pb. The Swiss mice were euthanized after 1, 2, 4 and 8 weeks of infection with Pb, and their spleens were removed for ex vivo analyzes. Histopathological evaluation revealed that the red pulp was the area most affected, presenting the highest concentration of yeasts, inflammatory cells and cells in apoptosis, with no observation of typical granuloma formation. The main physical–chemical changes were detected in the spectral ranges between 1730–1590 cm−1 and 1390–1280 cm−1 attributed to amide I and vibrational deformation mode of CH3 and CH2 molecules, respectively. The amide I was correlated to total protein content and CH3 and CH2 molecules to collagen of the spleen. The association between histological and physical–chemical methods enabled detection of several alterations in the spleen, including apoptosis, contributing to a better understanding of paracoccidioidomycosis, a tropical neglected disease.

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Protein-losing enteropathy in paracoccidioidomycosis identified by scintigraphy: report of three cases

Cited by 3 publications

References 7 publications

Ascaris lumbricoides causing infarction of the mesenteric lymph nodes and intestinal gangrene in a child: a case report

Ascaris lumbricoides causing infarction of the mesenteric lymph nodes and intestinal gangrene in a child: a case report

Case report: juvenile paracoccidioidomycosis with intestinal involvement

Combination of Histopathology and FT‐Raman Spectroscopy for the Study of Experimental Paracoccidioidomycosis in the Spleen

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