Protein‐losing Enteropathies in Malignancy

Waldmann, Thomas A.; Broder, Samuel; Strober, Warren

doi:10.1111/j.1749-6632.1974.tb14463.x

Cited by 35 publications

(6 citation statements)

References 25 publications

(2 reference statements)

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“…In eight patients with progressive and advanced malignancy of various types, Waterhouse (1975) showed that the total synthesis of IgG was increased to about twice normal and the mean survival time of the circulating immunoglobulin was short, indicating both a rapid distribution and decaying loss from the system. Waldmann et al (1974) suggested gastrointestinal excretion of immunoglobulins in certain patients with cancer, particularly gastrointestinal and pancreatic carcinomas. Such loss is usually associated with lymphopenia.…”

Section: Immunoglobulin Studiesmentioning

confidence: 99%

Quantitative change of serum protein and immunoglobulin in patients with solid cancers

Lee

1977

Journal of Surgical Oncology

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There are many quantitative changes of serum protein and immunoglobulin fractions in patients with cancer of various sites, excluding those with leukemic and lymphoproliferative disorders. The commonest change in serum proteins of patients with neoplastic disease is a reduction in albumin concentration and elevation of alpha globulins, especially alpha-2 fraction. Immunoglobulins (IgG, A,M) are a heterogenous group of proteins contained in the gamma, beta, and alpha-2 electrophoretic fractions of serum proteins. The IgG was found to be significantly increased in patients with cancer of the skin and lung, but decreased in patients with cancer of the prostate and breast. Serum IgM was reported to be elevated in patients with sarcoma, melanoma, brain tumors, but decreased in patients with carcinoma of the ovary. Serum IgA was found to be elevated in patients with cancer of epithelial secretory organs, such as skin, breast, head and neck, lung, gut, prostate, and uterine cervix. Whether these findings reflect specific changes of the humoral arm of tumor-host interaction remains to be investigated.

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Section: Immunoglobulin Studiesmentioning

confidence: 99%

Quantitative change of serum protein and immunoglobulin in patients with solid cancers

Lee

1977

Journal of Surgical Oncology

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“…No lymphatic duct dilation was observed in intralymphatic pressure due to lymphatic invasion. 7 In this case, protein leak scintigraphy showed diffuse accumulation from the ascending colon to the rectum, suggesting that the protein leak was from multiple colorectal adenomas as well as from a malignant tumor. In a previously reported case, colonic polyps were covered with a mucin-like material, suggesting that excessive secretion of mucin-containing proteins from multiple adenomas may be the cause of the protein-losing enteropathy.…”

Section: Discussionmentioning

confidence: 67%

A case of familial adenomatous polyposis with protein‐losing enteropathy treated by laparoscopic total colorectal resection: A literature review

Tubakihara

Sawayama

Komohara

et al. 2022

Asian J Endoscop Surgery

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Familial adenomatous polyposis (FAP) with protein‐losing enteropathy is a rare disorder and is difficult to treat medically. A 74‐year‐old female patient was referred to our hospital with a chief complaint of anorexia. Lower gastrointestinal endoscopy showed multiple adenomas from the ascending colon to the rectum and adenocarcinoma in the sigmoid colon and descending colon. Laboratory findings showed hypoalbuminemia (albumin 1.6 mg/dl). Protein leak scintigraphy using 99mTc‐HSAD found a protein leak from the colon. Although hypercaloric infusion was administered, the nutritional status was not improved and albumin transfusion was required. The patient underwent laparoscopic total proctocolectomy, ileal pouch‐anal anastomosis, and temporary ileostomy. She had a good postoperative course and the hypoalbuminemia normalized in a few weeks. The patient underwent temporary ileostomy reversal. Here we report a case of FAP with protein‐losing enteropathy who underwent laparoscopic total proctocolectomy, which resulted in improvement of the protein leak as well as cancer treatment.

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“…Hypoalbuminemia is one of the most frequent nonspecific abnormalities associated with cancer, and it is usually due to decreased synthesis of albumin. 1 Although this patient had lost a considerable amount of weight on a diet, her presentation was not characteristic of malnutrition, and most of the weight loss antedated the onset of her symptoms by at least a year. Also, she had a relatively low level of proteinuria, which would not be expected to lead to severe hypoproteinemia.…”

mentioning

confidence: 78%

“…Protein-losing enteropathy is a complication of many types of cancer, including lymphoma, 21 carcinoid tumor with the carcinoid syndrome, Kaposi's sarcoma, 22 leukemia, 23 and carcinomas, as well as one or more polyps of the gastrointestinal tract. 1 Patients with malignant melanoma may be at increased risk for secondary cancers associated with familial cancer syndromes, such as the Li-Fraumeni syndrome, 24 hereditary retinoblastoma, 25 and familial melanoma. 26 However, a hereditary cancer syndrome is not necessarily implicated in this case.…”

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confidence: 99%