Protein lipidation in health and disease: molecular basis, physiological function and pathological implication
Yuan Yuan,
Peiyuan Li,
Jianghui Li
et al.
Abstract:Posttranslational modifications increase the complexity and functional diversity of proteins in response to complex external stimuli and internal changes. Among these, protein lipidations which refer to lipid attachment to proteins are prominent, which primarily encompassing five types including S-palmitoylation, N-myristoylation, S-prenylation, glycosylphosphatidylinositol (GPI) anchor and cholesterylation. Lipid attachment to proteins plays an essential role in the regulation of protein trafficking, localisa… Show more
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