Protein-Lipid Relationships in Normal Dog Plasma

Russ, Ella M.; Raymunt, Julie

doi:10.1161/01.res.3.2.194

Cited by 6 publications

(4 citation statements)

References 8 publications

(3 reference statements)

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“…It thus appears probable that in the normal dog cholesterol enters in the same fashion as part of normal serum lipoproteins which in the dog are largely a-lipoproteins. 10 The rates we have determined appear to be estimates of the rates of entrance of a-lipoproteins into aortic wall. They should be considered approximations rather than precise estimates since they may have been affected somewhat by the behavior of labeled cholesterol once it was within the aortic wall.…”

Section: Resultsmentioning

confidence: 88%

Passage of Labeled Cholesterol into the Aortic Wall of the Normal Dog

Duncan

Buck

Lynch

1959

Circulation Research

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In the normal dog the rate of movement of cholesterol from the serum into the inner layer of the aortic wall is greatest at the proximal end of the aorta and decreases progressively along the length of the aorta until in the terminal aorta the rate is only about one sixth that in the proximal aorta. A similar gradient of rates was previously demonstrated for albumin which enters the aortic wall about three times as fast as cholesterol. The similarity of the gradients and the relative magnitude of the rates for cholesterol and albumin support the concept that cholesterol is carried into the aortic wall of the normal dog by the passage of the lipoproteins of which it is a part.

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Section: Resultsmentioning

confidence: 88%

Passage of Labeled Cholesterol into the Aortic Wall of the Normal Dog

Duncan

Buck

Lynch

1959

Circulation Research

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“…The androgen-derived progestin levonorgestrel increased postheparin plasma hepatic lipase (PH-HL) activity and decreased plasma high-density lipoprotein (HDL) lipid concentrations in a manner opposite to that of oestradiol. The relationships between PH-HL activity and HDL lipids suggest an important role for this enzyme as a mediator of sex hormone action on HDL.The sex differences in the distribution of plasma lipoproteins were demonstrated nearly three de¬ cades ago by Russ et al ( 1951). Young women were shown to have a relatively greater amount of alpha lipoprotein (HDL) and a correspondingly smaller amount of beta lipoprotein (LDL) than young men.…”

mentioning

confidence: 99%

“…The sex differences in the distribution of plasma lipoproteins were demonstrated nearly three de¬ cades ago by Russ et al ( 1951). Young women were shown to have a relatively greater amount of alpha lipoprotein (HDL) and a correspondingly smaller amount of beta lipoprotein (LDL) than young men.…”

mentioning

confidence: 99%

Effects of oestradiol and levonorgestrel on lipoprotein lipids and postheparin plasma lipase activities in normolipoproteinaemic women

Tikkanen

Nikkilä

Kuusi

et al. 1982

Acta Endocrinologica

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The effects of oestradiol and levonorgestrel on plasma lipoprotein cholesterol (Chol) and triglyceride (Tg) levels and on postheparin plasma lipoprotein lipase (LPL) and hepatic lipase (HL) activity were studied in 52 normolipoproteinaemic women. The androgen-derived progestin levonorgestrel increased postheparin plasma hepatic lipase (PH-HL) activity and decreased plasma high-density lipoprotein (HDL) lipid concentrations in a manner opposite to that of oestradiol. The relationships between PH-HL activity and HDL lipids suggest an important role for this enzyme as a mediator of sex hormone action on HDL.The sex differences in the distribution of plasma lipoproteins were demonstrated nearly three de¬ cades ago by Russ et al. ( 1951). Young women were shown to have a relatively greater amount of alpha lipoprotein (HDL) and a correspondingly smaller amount of beta lipoprotein (LDL) than young men. This stimulated the interest in the effects of sex hormones on plasma lipoproteins. Oestrogens were shown to increase alpha lipoprotein and decrease beta lipoprotein concentrations whereas androgens had the opposite effect (Russ et al. 1955). Also, oestrogens increased plasma very-low density lipo¬ protein (VLDL) concentrations whereas androgens reduced them (Furman et al. 1967). Later on nortestosterone-derived progestins were shown to have androgen-like effects on plasma lipoprotein levels (Silfverstolpe et al. 1979; Hirvonen et al. 1981), whereas progesterone and its dérivâtes were relatively inert in this respect (Svanborg & Vikrot 1966; Silfverstolpe et al. 1979; Hirvonen et al. 1981).The mechanism by which sex hormones exert their effects on plasma lipoprotein levels is not clear. Interestingly, they also influence postheparin plasma hepatic lipase (PH-HL) activity. Equine oestrogens have a marked suppressing effect on PH-HL activity whereas postheparin plasma lipo¬ protein lipase (PH-LPL) activity is not affected (Applebaum et al. 1977). A similar effect was observed during treatment with oestradiol valerate in hypercholesterolaemic post-menopausal women (Tikkanen et al. 1979). Conversely, the synthetic nortestosterone-derived progestin levonorgestrel is known to increase PH-HL activity (Tikkanen et al. 1981). In the present study we treated normo¬ lipoproteinaemic women with oestradiol and levo¬ norgestrel in order to clarify the possible role of hepatic lipase as mediator of sex hormone effects on lipoprotein lipids. Material and MethodsThree groups of women received hormone therapy. In Group 1 women were given oestradiol only, in Group 2 they received levonorgestrel only and in Group 3 a combination of both was given. The women in all three groups had normal plasma lipoprotein levels prior to hormone treatment. The mean pre-treatment concentra¬ tions are given in Table 1. Apart from symptoms related Third Department ofMedicine1,

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“…High-density lipoproteins (HDL) have gained much publicity in the last five years. Their role as a negative-risk indicator for atherosclerotic disease has been established by a number of ad hoc (6)(7)(8)(9)(10)(11)(12)(13)(14) and prospective (15)(16)(17)(18) studies in middleaged subjects. However, few data are available on geriatric subjects.…”

mentioning

confidence: 99%

High‐Density Lipoproteins and Peripheral Vascular Disease in Octo‐ and Nonagenarians

Schneider

1980

J American Geriatrics Society

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In a medical service for ambulant patients, 180 unselected octo- and nonagenarians were studied. They showed high-density lipoprotein (HDL) values similar to those reported for younger age groups. In 81 patients, a combination of various noninvasive angiologic techniques was used in addition to the history and physical examination. The frequencies of the clinical signs of peripheral arterial disease, and of stenoses and occlusions in the lower-limb vessels, differed significantly between three HDL-cholesterol subgroups, being highest in the group with the lowest HDL values.

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Protein-Lipid Relationships in Normal Dog Plasma

Cited by 6 publications

References 8 publications

Passage of Labeled Cholesterol into the Aortic Wall of the Normal Dog

Passage of Labeled Cholesterol into the Aortic Wall of the Normal Dog

Effects of oestradiol and levonorgestrel on lipoprotein lipids and postheparin plasma lipase activities in normolipoproteinaemic women

High‐Density Lipoproteins and Peripheral Vascular Disease in Octo‐ and Nonagenarians

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